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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 10-Q
(Mark One)
☒    QUARTERLY REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the quarterly period ended September 30, 2026
or
☐    TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from ___________ to ___________
Commission File Number: 000-55136
Skye Bioscience, Inc.
_____________________________________________________________
(Exact name of registrant as specified in its charter)
Nevada45-0692882
(State or other jurisdiction
of incorporation or organization)
(I.R.S. Employer
Identification No.)
11250 El Camino Real, Suite 100, San Diego, CA 92130
(Address of principal executive offices) (Zip Code)
(858) 410-0266
(Registrant’s telephone number, including area code)


__________________________N/A_______________________________
(Former name, former address and former fiscal year, if changed since last report)
Securities registered pursuant to Section 12(b) of the Act:
Title of each classTrading Symbol(s)Name of each exchange
on which registered
Common Stock, par value $0.001SKYE
The Nasdaq Stock Exchange LLC
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. ☒ Yes     ☐ No
Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). ☒ Yes     ☐ No
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large accelerated filer
☐
Accelerated filer
☐
Non-accelerated filer☒Smaller reporting company☒
Emerging growth company
☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). ☐ Yes ☒ No
As of November 10, 2026, there were 4,423,469 shares of the registrant's common stock, $0.001 par value, issued and outstanding.




TABLE OF CONTENTS
Condensed Consolidated Statements of Operations for the three and nine months ended September 30, 2026 and 2025 (Unaudited)
Condensed Consolidated Statements of Stockholders’ Equity for the three and nine months ended September 30, 2026 and 2025 (Unaudited)

2


CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS
This Quarterly Report on Form 10-Q contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical facts included in this Quarterly Report are forward-looking statements, including without limitation, statements regarding:

•delays in or failure to complete the Transaction (as defined herein), whether due to an inability by either party to satisfy one or more conditions to the closing of the Transaction (the "Closing" and such date, the "Closing Date"), including an inability to obtain required shareholder approvals or certain regulatory approvals, the occurrence of events or changes in circumstances that give rise to the termination of the Transaction Agreement (as defined herein) by either party, or otherwise;
•risks related to the pendency of the Transaction and its effect on our business, financial condition, results of operations, cash flows and stock price;
•diversion of management time and attention from ordinary course business operations to the Transaction and other potential disruptions to our business relating thereto;
•the period over which we estimate our existing cash and cash equivalents will be sufficient to fund our future operating expenses and capital expenditure requirements;
•our expectations regarding the termination of our Phase 2a CBeyond clinical trial;
•the timing, scope and likelihood of regulatory filings and approvals;
•expectations regarding the size, scope and design of future clinical studies;
•our manufacturing, commercialization, and marketing plans and strategies;
•our expectations regarding the approval and use of our product candidates;
•our competitive position and the development and impact of competing therapies that are or may become available;
•the rate and degree of market acceptance and clinical utility of product candidates we may develop;
•our estimates regarding expenses, future revenue, capital requirements and needs for additional financing;
•our future financial performance;
•the impact of laws and regulations;
•our ability to raise capital on favorable terms, or at all, to fund operations and to continue as a going concern;
•our ability to remediate the material weakness in our internal control over financial reporting; and
•statements relating to any pending litigation matters.
When used herein, words including “anticipate,” “believe,” “can,” “continue,” “could,” “designed,” “estimate,” “expect,” “forecast,” “goal,” “intend,” “may,” “might,” “plan,” “planning,” “possible,” “potential,” “predict,” “project,” “should,” “target,” “will,” “would” and similar expressions are intended to identify forward-looking statements, though not all forward-looking statements use these words or expressions.
3


All forward-looking statements are based upon the Company’s current expectations and various assumptions. The Company believes there is a reasonable basis for its expectations and beliefs, but they are inherently uncertain. The Company may not realize its expectations, and its beliefs may not prove correct. Actual results could differ materially from those described or implied by such forward-looking statements as a result of various important risks and uncertainties, including, without limitation: consummating the Transaction in the anticipated timeframe, if at all; the occurrence of any event, change or other circumstance that could give rise to the termination of the Transaction Agreement; uncertainties as to the ability to obtain stockholder approval; the possibility that competing acquisition proposals will be made; the possibility that various closing conditions for the Transaction may not be satisfied or waived, including that a governmental entity may prohibit, delay or refuse to grant approval for the consummation of the Transaction, or only grant approval subject to adverse conditions or limitations; the effects of the Transaction on relationships with employees, suppliers, other business partners or governmental entities, including the risk that the Transaction adversely affects employee retention; the difficulty of predicting the timing or outcome of regulatory approvals or actions; the impact of competitive products and pricing; the risk that Redx may not realize the potential benefits of the Transaction, including the possibility that the expected benefits from the proposed Transaction will not be realized or will not be realized within the expected time period and that Redx (as defined below) and the Company will not be integrated successfully or that such integration may be more difficult, time-consuming or costly than expected; the risks related to disruption of management's time from ongoing business operations as a result of the Transaction; risks that the Transaction disrupts current plans and operations; changes in the Company's business during the period between announcement and Closing; any legal proceedings and/or regulatory actions that may be instituted related to the Transaction; other business effects, including the effects of industry, economic or political conditions outside of the companies’ control; costs and expenses related to the Transaction; actual or contingent liabilities; the effects of the Transaction, or the announcement thereof, on the Company’s stock price and/or operating results; the initiation and design of any future clinical trials of nimacimab will be impacted by the Company’s capital resources; the Company’s ability to protect its intellectual property; risks associated with the Company’s common stock; risks and uncertainties associated with any pending litigation matters; and the other important factors discussed under the caption “Risk Factors” in this Quarterly Report and the Company’s filings with the Securities and Exchange Commission (the "SEC"), including in its Annual Report on Form 10-K for the year ended December 31, 2025, which are accessible on the SEC’s website at www.sec.gov and the Investors section of the Company’s website.
Any such forward-looking statements represent management’s estimates as of the date of this Quarterly Report. While the Company may elect to update such forward-looking statements at some point in the future, except as required by law, it disclaims any obligation to do so, even if subsequent events cause the Company’s views to change. These forward-looking statements should not be relied upon as representing the Company’s views as of any date subsequent to the date of this Quarterly Report.
4


PART I - FINANCIAL INFORMATION
Item 1. Financial Statements
5


SKYE BIOSCIENCE, INC. AND SUBSIDIARIES
CONDENSED CONSOLIDATED BALANCE SHEETS
September 30,
2026
December 31,
2025
(Unaudited)
ASSETS
Current assets
Cash and cash equivalents$4,815,851 $5,882,498 
Short-term investments— 19,854,723 
Prepaid expenses206,984 504,890 
Other current assets12,437 852,036 
Total current assets5,035,272 27,094,147 
Property and equipment, net20,430 898,930 
Operating lease right-of-use asset8,580 266,646 
Other assets8,309 53,910 
Total assets$5,072,591 $28,313,633 
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities
Accounts payable$2,448,444 $2,033,431 
Accrued payroll liabilities134,686 1,269,474 
Other current liabilities1,083,837 2,643,840 
Estimate for accrued legal contingencies and related expenses— 2,069,067 
Insurance premium loan payable35,763 — 
Operating lease liability, current portion9,452 189,647 
Total current liabilities3,712,182 8,205,459 
Non-current liabilities
Operating lease liability, net of current portion— 83,999 
Total liabilities3,712,182 8,289,458 
Commitments and contingencies (Note 10)
Stockholders’ equity
Preferred stock, $0.001 par value; 200,000 shares authorized at September 30, 2026 and December 31, 2025; no shares issued and outstanding at September 30, 2026 and December 31, 2025
— — 
Common stock, $0.001 par value; 37,500,000 and 12,500,000 shares authorized at September 30, 2026 and December 31, 2025; 4,423,469 and 4,172,267 shares issued and outstanding at September 30, 2026 and December 31, 2025, respectively
4,423 4,172 
Additional paid-in-capital211,457,301 206,894,489 
Accumulated deficit(210,101,315)(186,874,486)
Total stockholders’ equity1,360,409 20,024,175 
Total liabilities and stockholders’ equity$5,072,591 $28,313,633 
See accompanying notes to the unaudited condensed consolidated financial statements.
Common share and per share amounts have been retroactively adjusted to reflect a 1-for-8 reverse stock split effected on August 24, 2026, throughout the unaudited condensed consolidated financial statements unless otherwise stated.

6


SKYE BIOSCIENCE, INC. AND SUBSIDIARIES
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
(UNAUDITED)
For the Three Months Ended
September 30,
For the Nine Months Ended
September 30,
2026202520262025
Operating (income) expenses
Research and development$1,316,222 $9,357,444 $13,193,834 $30,892,454 
General and administrative3,657,461 3,907,090 12,265,518 12,375,567 
Change in estimate for legal contingency(5,000,000)— (1,750,000)— 
Total operating (income) expenses(26,317)13,264,534 23,709,352 43,268,021 
Operating income (loss)26,317 (13,264,534)(23,709,352)(43,268,021)
Other (income) expense
Interest expense3,299 — 8,797 — 
Interest and other income, net(49,099)(418,474)(321,922)(1,609,807)
Gains from asset sales— (91,400)(178,200)(180,763)
Other expense2,991 — 5,402 — 
Total other (income) expense, net(42,809)(509,874)(485,923)(1,790,570)
Income (loss) before income taxes69,126 (12,754,660)(23,223,429)(41,477,451)
Provision for income taxes— — 3,400 5,400 
Net income (loss )$69,126 $(12,754,660)$(23,226,829)$(41,482,851)
Income (loss) per common share:
Basic$0.01 $(2.57)$(4.68)$(8.37)
Diluted$0.01 $(2.57)$(4.68)$(8.37)
Weighted average shares of common stock outstanding used to compute income (loss) per share:
Basic4,960,912 4,958,241 4,960,656 4,956,814 
Diluted4,994,551 4,958,241 4,960,656 4,956,814 
See accompanying notes to the unaudited condensed consolidated financial statements.
Common share and per share amounts have been retroactively adjusted to reflect a 1-for-8 reverse stock split effected on August 24, 2026, throughout the unaudited condensed consolidated financial statements unless otherwise stated.
7


SKYE BIOSCIENCE, INC. AND SUBSIDIARIES
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
(UNAUDITED)
For the Nine Months Ended
September 30,
20262025
Cash flows from operating activities:
Net Loss$(23,226,829)$(41,482,851)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization361,809 543,343 
Stock-based compensation expense4,566,214 6,149,154 
Gains from asset sales(178,200)(180,763)
Impairment and losses on disposal of property and equipment603,540 — 
Change in estimate for legal contingencies(1,750,000)— 
Changes in assets and liabilities:
Prepaid expenses619,769 (3,510,349)
Right-of-use assets170,367 — 
Other current assets839,599 1,309,369 
Other assets45,601 — 
Accounts payable415,013 2,187,002 
Accrued payroll liabilities(1,134,788)(193,481)
Operating lease liability(264,194)(133,745)
Other current liabilities(1,879,070)2,016,279 
Net cash used in operating activities(20,811,169)(33,296,042)
Cash flows from investing activities:
Proceeds from the sale of assets, net of sales costs178,200 180,763 
Maturities/(purchase) of short-term investments19,854,723 (16,871,229)
Purchase of property and equipment— (6,312)
Cash from asset disposition850 — 
Net cash provided by (used in) investing activities20,033,773 (16,696,778)
Cash flows from financing activities:
Purchase under employee stock purchase plan6,274 18,158 
Cash paid in lieu of fractional shares from reverse stock split(9,425)— 
Repayment of insurance premium loan payable(286,100)— 
Net cash (used in) provided by in financing activities(289,251)18,158 
Net decrease in cash and cash equivalents(1,066,647)(49,974,662)
Cash and cash equivalents, beginning of period$5,882,498 $68,415,741 
Cash and cash equivalents, end of period$4,815,851 $18,441,079 
Cash paid during the year for:
Interest$8,797 $— 
Income taxes3,400 5,400 
Supplemental disclosures of non-cash financing activities:
Financing of D&O insurance premium$321,863 $— 

See accompanying notes to the unaudited condensed consolidated financial statements.
8


SKYE BIOSCIENCE, INC. AND SUBSIDIARIES
CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY
(UNAUDITED)

Common StockAdditional
Paid-In
Capital
Accumulated
Deficit
Total
Stockholders’
Equity
SharesAmounts
Balance, January 1, 20264,172,267$4,172 $206,894,489 $(186,874,486)$20,024,175 
Stock-based compensation expense117 — 1,496,990 — 1,496,990 
Exercise of pre-funded warrants218,476 218 (218)— — 
Net loss for the three months ended March 31, 2026— — — (12,509,361)(12,509,361)
Balance, March 31, 20264,390,860$4,390 $208,391,261 $(199,383,847)$9,011,804 
Stock-based compensation expense1,055 1 1,271,208 — 1,271,209 
Purchases under employee stock purchase plan1,050 1 6,273 — 6,274 
Net loss for the three months ended June 30, 2026— — — (10,786,594)(10,786,594)
Balance, June 30, 20264,392,965$4,392 $209,668,742 $(210,170,441)$(497,307)
Stock-based compensation expense— — 1,798,015 — 1,798,015 
Exercise of pre-funded warrants34,70835 (35)— — 
Cash settlement of fractional shares in connection with reverse stock split(4,204)(4)(9,421)— (9,425)
Net income for the three months ended September 30, 2026— — — 69,126 69,126 
Balance, September 30, 20264,423,469$4,423 $211,457,301 $(210,101,315)$1,360,409 
9



Common StockAdditional
Paid-In
Capital
Accumulated
Deficit
Total
Stockholders’
Equity
SharesAmounts
Balance, January 1, 20253,871,820$3,872 $199,097,524 $(130,949,672)$68,151,724 
Stock-based compensation expense— — 2,201,909 — 2,201,909 
Net loss for the three months ended March 31, 2025— — — (11,103,319)(11,103,319)
Balance, March 31, 20253,871,820$3,872 $201,299,433 $(142,052,991)$59,250,314 
Stock-based compensation expense469 — 2,033,109 — 2,033,109 
Purchases under employee stock purchase plan1,225 1 18,157 — 18,158 
Net loss for the three months ended June 30, 2025— — — (17,624,872)(17,624,872)
Balance, June 30, 20253,873,514$3,873 $203,350,699 $(159,677,863)$43,676,709 
Stock-based compensation expense117— 1,914,136 — 1,914,136 
Net loss for the three months ended September 30, 2025— — — (12,754,660)(12,754,660)
Balance, September 30, 20253,873,631$3,873 $205,264,835 $(172,432,523)$32,836,185 
See accompanying notes to the unaudited condensed consolidated financial statements.
Common share and per share amounts have been retroactively adjusted to reflect a 1-for-8 reverse stock split effected on August 24, 2026, throughout the unaudited condensed consolidated financial statements unless otherwise stated.
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SKYE BIOSCIENCE, INC. AND SUBSIDIARIES
NOTES TO THE CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
(UNAUDITED)
1. Organization, Basis of Presentation and Significant Accounting Policies

Nature of Operations

Skye Bioscience, Inc. (the “Company” or “Skye”) was incorporated in Nevada on March 16, 2011. The Company is a clinical stage biotechnology company that has developed next-generation molecules that modulate G-protein-coupled receptors ("GPCRs") to treat obesity, overweight, and related conditions. In the second quarter of 2026, the Company paused all research and development activities for nimacimab.

Our lead product candidate, nimacimab, was being developed for weight loss in patients with obesity and overweight. In October 2025, results from its CBeyond Phase 2a trial demonstrated no difference in weight loss at 26-weeks between placebo and nimacimab-alone, while there was a significant difference in weight loss when nimacimab was combined with semaglutide compared to semaglutide alone.

In March 2026, the Company initiated an expansion study (Part C) of the CBeyond Phase 2a trial to assess preliminary safety and pharmacokinetic (PK) profile of nimacimab administered intravenously (IV). The expansion study comprised two cohorts of nimacimab monotherapy (400 mg IV and 600 mg IV) compared to placebo administered weekly over 15 weeks (16 doses), with a 12 week follow up period, to generate preliminary monotherapy safety, PK, and exploratory efficacy data. Within each dose cohort, 8 participants were randomized in a 3:1 ratio to nimacimab (n=6) or placebo (n=2).

Since inception, the Company had devoted substantially all its efforts to securing its product pipeline, carrying out research and development, preparing for and conducting clinical trials, building infrastructure and raising capital. Following the Company's review of the rapidly changing anti-obesity medicine landscape and the potential commercial success of nimacimab's target product profile, in the second quarter of 2026, Skye management determined that in order to maximize shareholder value the CBeyond trial, including the Part C expansion study, was terminated and all associated R&D activities for nimacimab were paused. On April 19, 2026 the Company engaged Stifel, Nicolaus & Company, Incorporated ("Stifel") as its exclusive financial advisor to assist in evaluating strategic alternatives. Following these actions, the Company’s activities have primarily focused on pursuing the proposed transaction with Redx Pharma Limited. See Note 2, Pending Redx Transaction and Related Financings, for additional information regarding the proposed transaction and related financing arrangements.

Pending Transaction with Redx Pharma Limited

On August 14, 2026, Skye entered into a transaction agreement (“Transaction Agreement”) with Redx Pharma Limited with registered number 07368089 (“Redx”), a private limited company incorporated in England and Wales. Pursuant to the Transaction Agreement, and subject to the terms and conditions set forth therein, Skye will acquire the entire issued and to be issued share capital of Redx pursuant to a scheme of arrangement under Part 26 of the United Kingdom Companies Act 2006 (the “Scheme of Arrangement” and such transaction, the “Transaction”). See Note 2, Pending Redx Transaction and Related Financings, for additional information.

In anticipation of the Transaction Agreement, the Company initiated a reduction in operating activities during the second and third quarters of 2026. These actions included a workforce reduction, the disposition of certain manufacturing-related assets that were no longer expected to be used in operations, and other activities associated with the wind-down of the Company's legacy operations. As a result, the Company recognized certain non-recurring charges during the three and nine months ended September 30, 2026. Additional information regarding the operating reductions and related asset impairment is included in Note 5, Property and equipment, net, and additional information regarding the Transaction Agreement is included in Note 2, Pending Redx Transaction and Related Financings.

Reverse Stock Split
August 2026 Reverse Stock Split
On August 12, 2026, the Company filed a Certificate of Change with the Secretary of State of the State of Nevada to effect a 1-for-8 reverse stock split of its issued and outstanding common stock (the “2026 Reverse Stock Split”), effective at 12:01 a.m. Eastern Time on August 24, 2026. The Company’s common stock began trading on a split-adjusted basis on The Nasdaq Capital Market on August 24, 2026. In connection with the 2026 Reverse Stock Split, the number of authorized shares of
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common stock was proportionately reduced from 300,000,000 to 37,500,000, and the par value remained unchanged at $0.001 per share. No fractional shares were issued; stockholders otherwise entitled to fractional shares received cash in lieu thereof.

Unless otherwise indicated, all common share and per-share amounts, including weighted-average shares outstanding and loss per share, and the number of shares underlying outstanding stock options, restricted stock units and warrants, together with the related exercise prices, as applicable, presented in these unaudited condensed consolidated financial statements and accompanying notes have been retrospectively adjusted to reflect the 2026 Reverse Stock Split for all periods presented.
Impact of Geopolitical and Macroeconomic Factors

It is possible that the Company may encounter supply chain issues related to global economic and political conditions such as a lack of production or laboratory resources, pandemics or cyberattacks that could cause business disruptions and clinical trial delays which will need to be managed in the future. There may also be significant uncertainty resulting from the impact of other geopolitical and macroeconomic factors, including global pandemics, tariffs, inflation, supply chain issues, fluctuating interest rates, future bank failures and disruptions to the supply chain as a result of increased geopolitical tensions between the U.S. and its international trade partners, including China and Iran.
Liquidity
The Company has incurred operating losses and negative cash flows from operations since inception and as of September 30, 2026, had a working capital of $1,323,090 and an accumulated deficit of $210,101,315. As of September 30, 2026, the Company had unrestricted cash and cash equivalents in the amount of $4,815,851. For the three months ended September 30, 2026, the Company incurred income from operations of $26,317. For the three months ended September 30, 2025, the Company incurred loss from operations of $13,264,534. For the nine months ended September 30, 2026 and 2025, the Company incurred losses from operations of $23,709,352 and $43,268,021, respectively. For the three months ended September 30, 2026, the Company incurred net income of $69,126. For the three months ended September 30, 2025, the Company incurred a net loss of $12,754,660. For the nine months ended September 30, 2026 and 2025, the Company incurred net losses of $23,226,829 and $41,482,851, respectively. The Company expects to continue to incur significant losses through the end of 2026 and expects to incur significant losses and negative cash flows from operations in the future.
The Company’s continued existence is dependent on its ability to close its proposed Transaction or to raise sufficient additional funding to cover operating expenses. As of the date that these financials are filed, management estimates that the Company has sufficient capital through the Closing. However, the Company's continued operations beyond the fourth quarter of 2026 will depend on its ability to complete the proposed Transaction or to successfully raise additional capital through various potential sources, such as equity and/or debt financings, or strategic relationships. If adequate funds are not available to the Company when needed it will be required to curtail or perhaps cease operations which would, in turn, further raise substantial doubt about its ability to continue as a going concern. These conditions give rise to substantial doubt as to the Company’s ability to continue as a going concern within one year after the date that these financial statements are issued.

The Company is a party to a legal proceeding with a former employee (see Note 10, Commitments and Contingencies). On November 10, 2026, a jury returned a unanimous verdict in favor of the Company on all claims, in the retrial of that matter (see Note 12, Subsequent Events). As of September 30, 2026, the estimated legal contingency is $0, excluding accrued legal expenses.

The Company does not believe that inflation has had a material impact on its operating results during the periods presented. However, inflation has had, and may continue to have, an impact on general and administrative costs such as professional fees, employee costs and travel costs, and may in the future adversely affect the Company's operating results. In addition, increased inflation has had and may continue to have an effect on interest rates. Increased interest rates may adversely affect the terms under which the Company can obtain any potential additional funding.
Nasdaq Communications

As previously disclosed by the Company in its Current Report on Form 8-K filed with the SEC on August 18, 2026, the Listing Qualifications Department of The Nasdaq Stock Market LLC ("Nasdaq") notified the Company that its stockholders’ deficit of $497,307 as of June 30, 2026 did not satisfy the $2,500,000 minimum stockholders’ equity requirement under Nasdaq Listing Rule 5550(b)(1). Nasdaq provided the Company until October 2, 2026 to submit a plan to regain compliance. The Company has submitted its initial plan to regain compliance and is actively working with Nasdaq as it reviews and responds to the Company's plan. If Nasdaq accepts the plan, it may grant an extension of up to 180 calendar days from the notification date, or until
12


February 14, 2027, for the Company to demonstrate compliance. As of September 30, 2026, the Company’s stockholders’ equity was $1,360,409.

The Company’s common stock continues to trade on The Nasdaq Capital Market under the symbol “SKYE” at this time. While the Company plans to review all available options, there can be no assurance that the Company will regain compliance with the minimum stockholders’ equity requirement or maintain compliance with other applicable Nasdaq listing requirements.

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information and the instructions to Form 10-Q and Article 8 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. Interim financial results are not necessarily indicative of results anticipated for the full year, or any future periods.
The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the unaudited condensed consolidated financial statements and the accompanying notes. Actual results could differ from those estimates.
The unaudited condensed consolidated financial statements included in this Quarterly Report on Form 10-Q should be read in conjunction with the audited consolidated financial statements and notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2025, from which the prior year balance sheet information herein was derived.
Certain reclassifications have been made to the amounts in prior periods to conform to the current period’s presentation, including reclassifying discovery research and development expense amounts from external clinical development expenses into other research and development expenses, as described in Note 11, Segment Reporting. Such reclassifications did not have a material impact on the accompanying unaudited condensed consolidated financial statements.
The unaudited condensed consolidated financial statements and notes thereto give retrospective effect for the 2026 Reverse Stock Split for all periods presented. All common stock, options exercisable for common stock, restricted stock units, warrants, and per share amounts contained in the unaudited condensed consolidated financial statements have been retrospectively adjusted to reflect the 2026 Reverse Stock Split for all periods presented.
During the nine months ended September 30, 2026, except as described below under "Property and Equipment, net," there were no changes to the Company's significant accounting policies as described in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2025.
Property and Equipment, net
Property and equipment is stated at cost less accumulated depreciation and amortization. Depreciation is calculated using the straight-line method over the estimated useful lives of the assets, generally three to five years. Leasehold improvements are amortized over the shorter of the estimated useful life of the improvements or the remaining lease term. Expenditures for repairs and maintenance, which do not extend the useful life of the property and equipment, are expensed as incurred. Upon retirement, the asset cost and related accumulated depreciation are relieved from the accompanying unaudited condensed consolidated balance sheets.
The Company evaluates long-lived assets for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be recoverable. Recoverability is assessed by comparing the carrying amount of the asset to the estimated undiscounted future cash flows expected to result from the asset's use and eventual disposition. If the carrying amount is determined to be unrecoverable, an impairment loss is recognized for the amount by which the carrying amount exceeds the asset's fair value. During the nine months ended September 30, 2026, the Company recognized an impairment loss of $589,660 related to certain clinical manufacturing fixed assets in the second quarter of 2026. The impairment resulted from changes in the Company's strategic plans and the determination that the carrying amounts of the assets were no longer recoverable. See Note 5, Property and equipment, net, for additional information.
Recent Accounting Pronouncements Not Yet Adopted
In November 2024, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update ("ASU") 2024-03, Income Statement - Reporting Comprehensive Income - Expense Disaggregation Disclosures (Subtopic 220-40): Disaggregation of Income Statement Expenses, which requires additional disclosure of the nature of expenses included in the income statement. The standard requires disclosures about specific types of expenses included in the expense captions presented in the income statement as well as disclosures about selling expenses. This ASU is effective for fiscal years beginning after December 15, 2026, and interim periods beginning after December 15, 2027, with early adoption permitted. The requirements
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should be applied on a prospective basis while retrospective application is permitted. The Company is currently evaluating the impact the adoption of this ASU will have on its consolidated financial statements and related disclosures.
In December 2025, the FASB issued ASU 2025-11 – Interim Reporting (“ASU 2025-11”) which is intended to improve the navigability of the guidance in ASC 270, Interim Reporting, and clarify when it applies. Under the amendments, an entity is subject to ASC 270 if it provides interim financial statements and notes in accordance with GAAP. ASU 2025-11 also addresses the form and content of such financial statements, interim disclosures requirements, and establishes a principle under which an entity must disclose events since the end of the last annual reporting period that have a material impact on the entity. ASU 2025-11 is effective for interim reporting periods within annual reporting periods beginning after December 15, 2027, and early adoption is permitted. The Company is currently evaluating the impact the adoption of ASU 2025-11 may have on the Company’s consolidated financial statements and disclosures.
In December 2025, the FASB issued its final ASU which makes improvements to the Accounting Standards Codification ("ASC") in response to feedback from stakeholders. This standard, issued as ASU 2025-12, specifically updates the ASC for a broad range of topics arising from technical corrections, unintended application of the ASC, clarifications, and other minor improvements. This update is effective for annual reporting periods beginning after December 15, 2026, including interim reporting periods within those annual reporting periods. The Company is currently evaluating the effect of this guidance on its financial statements and related disclosures.
2. Pending Redx Transaction and Related Financings

Transaction Agreement with Redx Pharma Limited

On August 14, 2026, Skye entered into the Transaction Agreement with Redx. Subject to the terms and conditions of the Transaction Agreement, the Company will acquire the entire issued and to be issued share capital of Redx pursuant to a scheme of arrangement under Part 26 of the United Kingdom Companies Act 2006 (the “Transaction”). The Transaction had not closed as of September 30, 2026. Completion remains subject to applicable closing conditions, including required stockholder approvals, sanction of the Scheme of Arrangement by the applicable court in England and Wales, and Nasdaq approval of the combined company’s initial listing application.

Under the Transaction Agreement, following the effective time of the Scheme of Arrangement (the “Effective Time”), each Scheme Share (as defined in the Scheme of Arrangement) shall be transferred from the holders of the Scheme Shares to the Company in exchange for a number of validly issued, fully paid and non-assessable shares of common stock of the Company, par value of $0.001 per share or, or, if elected for a part or all of the Scheme Shares held by an Eligible Electing Shareholder (as defined in the Transaction Agreement) shares of non-voting common stock of the Company to be established prior to the Effective Time, which shares will be convertible into shares of common stock on a one-for-one basis (the “Non-Voting Common Stock” and, the shares of common stock and/or Non-Voting Common Stock to be issued pursuant to the Transaction Agreement, the “Share Deliverables”), calculated in accordance with the exchange ratio set forth in the Transaction Agreement, which is subject to certain adjustments as set forth therein (the “Exchange Ratio”).

Concurrently with entering into the Transaction Agreement, Redx entered into a subscription agreement pursuant to which, on August 27, 2026, Redx issued series A Preferred shares in the capital of Redx (the “Series A Shares”) for an aggregate purchase price of $36.0 million (the “Series A Financing”), which Series A Shares form part of the Scheme Shares.

Skye Contingent Value Rights Agreement

Immediately prior to the Effective Time, the Company and a rights agent are expected to enter into a contingent value rights agreement (the “Skye CVR Agreement”), pursuant to which holders of record of common stock as of the close of business on the last business day prior to the day on which the Effective Time occurs will receive one contingent value right (each a "Skye CVR") for each outstanding share of common stock held as of such date. Pursuant to the Skye CVR Agreement, each Skye CVR holder will be entitled to receive their pro rata share of an aggregate cash payment equal to 90% of the net proceeds, if any, received by the combined company as a result of payments (the "Skye CVR Payments") made to the combined company of any upfront, milestone, royalty and other payments received under any disposition agreement related to certain of the Company’s pre-Transaction assets. The Skye CVR Payments, if any, will become payable to the rights agent for subsequent distribution to the Skye CVR holders. In the event that no such proceeds are received during the CVR Term (as defined in the Skye CVR Agreement), holders of the Skye CVRs will not receive any payment pursuant to the Skye CVR Agreement. There can be no assurance that any Skye CVR holders will receive any Skye CVR Payments. The right to the contingent payments contemplated by the Skye CVR Agreement is a contractual right only and is not transferable, except in the limited circumstances specified in the Skye CVR Agreement.

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Redx Contingent Value Rights Agreement

Immediately prior to the Effective Time, Redx and a rights agent are expected to enter into a contingent value rights agreement (the “Redx CVR Agreement”), pursuant to which holders of record of Redx ordinary shares as of the close of business on the last business day prior to the day on which the Effective Time occurs will receive one contingent value right (each, a "Redx CVR") for each outstanding Redx ordinary share held as of such date. Pursuant to the Redx CVR Agreement, each Redx CVR holder will be entitled to receive, at such holder's election, in the form of shares of common stock or Non-Voting Common Stock (the "Redx CVR Stock"), their pro rata share of an aggregate cash payment equal to 100% of the net proceeds, if any, received by the Company as a result of payments made to the Company of any upfront, milestone, royalty and other payments received under any disposition agreement related to certain of Redx’s pre-Transaction assets. The Redx CVR Stock, if any, will become issuable for subsequent delivery by the rights agent to the Redx CVR holders. In the event that no such proceeds are received during the term of the Redx CVR Agreement, holders of the Redx CVRs will not receive any deliveries pursuant to the Redx CVR Agreement. There can be no assurance that any Redx CVR holders will receive any Redx CVR Stock. The right to the contingent payments contemplated by the Redx CVR Agreement is a contractual right only and is not transferable, except in the limited circumstances specified in the Redx CVR Agreement.

Concurrent Financing

Concurrently with entering into the Transaction Agreement, the Company entered into a securities purchase agreement (the “PIPE Securities Purchase Agreement”) with certain accredited investors (the “Investors”). Pursuant to the PIPE Securities Purchase Agreement, and subject to the terms and conditions therein, the Company agreed to sell, and the Investors agreed to purchase, immediately after the Closing, shares of common stock and, as applicable pursuant to the terms of the PIPE Securities Purchase Agreement, shares of Non-Voting Common Stock for an aggregate purchase price of $67.9 million, which may increase to up to $72.9 million, subject to certain conditions set forth in a side letter between the Company and an existing investor (the “Side Letter”) pursuant to which such investor has agreed to invest up to an additional $5.0 million, subject to the satisfaction of certain conditions in the Side Letter (such financing, the “Concurrent Financing”). The closing of the Concurrent Financing is anticipated to occur immediately following the Closing on the Closing Date, subject to the satisfaction of customary closing conditions.

Equity Line of Credit and Warrant

On August 21, 2026, the Company entered into a securities purchase agreement (the “ELOC Securities Purchase Agreement”) with a fund affiliated with Redmile Group, LLC (“Buyer”), pursuant to which, and in accordance with the terms and conditions set forth therein, (i) the Company will be required, subject to the limitations and conditions set forth therein, to sell to Buyer, and Buyer will be obligated to purchase, shares of common stock and, as applicable pursuant to the terms of the ELOC Securities Purchase Agreement, shares of Non-Voting Common Stock, with an aggregate purchase price of up to $22.0 million, which amount shall be reduced by the amount, if any, by which the aggregate gross equity proceeds actually funded to the Company in connection with the closing of the issuance and sale of equity securities by the Company or Redx (including pursuant to the PIPE Securities Purchase Agreement and certain additional equity financings occurring or closing concurrently or in connection therewith, including the Series A Financing) exceeds $103.0 million; provided that, if such amount equals or exceeds $125.0 million, the Company shall not be required to sell, and Buyer shall not be required to purchase, any securities pursuant to the ELOC Securities Purchase Agreement; and (ii) the Company agreed to issue to Buyer on the Closing Date a warrant to purchase up to a number of shares of common stock and/or Non-Voting Common Stock equal to $5.0 million divided by the price per share of common stock paid by the Investors pursuant to the PIPE Securities Purchase Agreement, in accordance with the terms set forth therein (the “Warrant”).
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3. Fair Value Measurement
The following table sets forth the Company’s financial instruments that were measured at fair value on a recurring basis by level within the fair value hierarchy:
Fair Value Measurement as of September 30, 2026
Valuation
HierarchyTotal
Assets:
Money market funds (included in cash and cash equivalents)Level 1$3,134,753 
Total cash equivalents and marketable securities$3,134,753 

4. Prepaid Expenses, Other Current Assets and Liabilities

Prepaid expenses consist of the following:
September 30, 2026December 31, 2025
Prepaid clinical expenses$— $231,493 
Prepaid insurance120,599 90,807 
Other prepaid expenses86,385 182,590 
$206,984 $504,890 
Other current assets consist of the following:
September 30, 2026December 31, 2025
Vendor deposits— 827,781 
Other tax receivables4,464 10,474 
Other current assets7,973 13,781 

$12,437 $852,036 
Other current liabilities consist of the following:
September 30, 2026December 31, 2025
Research and development costs$— $2,518,724 
Legal expenses1,063,780 88,838 
Consulting and professional fees20,057 26,356 
Other accrued liabilities— 9,922 
$1,083,837 $2,643,840 
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5. Property and equipment, net
Property and equipment, net consists of the following:
September 30, 2026December 31, 2025
Machinery and equipment$11,150 $1,527,419 
Computer equipment61,281 96,744 
Furniture and fixtures
18,999 24,496 
Leasehold improvements13,954 23,918 
   Total property and equipment, gross105,384 1,672,577 
Less: accumulated depreciation and amortization
(84,954)(773,647)
Total property and equipment, net$20,430 $898,930 
During the second quarter of 2026, the Company began winding down its existing operations in in connection with its strategic review process and evaluation of the proposed Transaction Agreement. As a result, management determined that certain reusable manufacturing chromatography materials previously capitalized as machinery and equipment would no longer be used in the Company's operations.
Management evaluated these assets under ASC 360, Property, Plant, and Equipment, and concluded that the carrying amounts were not recoverable. In reaching this conclusion, management considered that the assets would no longer be used in operations, could not be repurposed for alternative internal use, were not intended to be sold, and that no active secondary market or other market participants were identified from whom the Company could reasonably expect to realize proceeds upon disposition.
Accordingly, the Company estimated the fair value of the assets to be zero and recorded a non-cash loss on disposal of approximately $589,660 during the nine months ended September 30, 2026. The impairment loss was included within research and development expenses in the accompanying unaudited condensed consolidated statements of operations for the nine months ended September 30, 2026.
6. Warrants
There are significant judgments and estimates inherent in the determination of the fair value of the Company’s warrants. These judgments and estimates include assumptions regarding the Company’s future operating performance and the determination of the appropriate valuation methods.
Warrants
Warrants vested and outstanding as of September 30, 2026, are summarized as follows:
SourceExercise
Price
Weighted
Average
Remaining
Contractual
Term
(Years)
Number of
Warrants
Outstanding
2016 Common Stock Warrants to Service Providers2,300.00 0.0820 
August 2023 Convertible Note Common Stock Warrants41.29 6.8842,500 
August 2023 PIPE Financing Common Stock Warrants41.29 6.88290,691 
January 2024 Pre-Funded Warrants Common Stock0.008 Indefinite534,095 
Total warrants outstanding as of September 30, 2026867,306
As of September 30, 2026, all of the Company's warrants are fully vested.
Warrant Exercises
Pre-Funded Warrant Exercises
On January 29, 2024, the Company entered into a Securities Purchase Agreement with certain institutional investors, pursuant to which on January 31, 2024, the Company issued an aggregate of 1,464,208 shares of common stock and 1,247,342 pre-
17


funded warrants (the "Pre-Funded Warrants") to purchase up to 1,247,342 shares of common stock (the "January 2024 PIPE Financing") for an aggregate purchase price of $49,991,010.
On March 11, 2026, 218,750 Pre-Funded Warrants issued in the January 2024 PIPE Financing with an intrinsic value of $174,519 were exercised on a cashless basis, resulting in the issuance of 218,476 shares of Company's common stock.
On July 15, 2026, 34,761 Pre-Funded Warrants issued in the January 2024 PIPE Financing with an intrinsic value of $188,534 were exercised on a cashless basis, resulting in the issuance of 34,708 shares of Company's common stock.

7. Stock-Based Compensation
Reverse Stock Split

August 2026 Reverse Stock Split
All share and per-share amounts presented in this note have been retrospectively adjusted to reflect the 2026 Reverse Stock Split described in Note 1, Nature of Operations and Business Activities.
Stock Incentive Plan
On October 31, 2014, the Board of Directors of the Company (the "Board") approved the Company’s 2014 Omnibus Incentive Plan (the "2014 Omnibus Incentive Plan"). On June 14, 2022, the Board approved the 2014 Amended and Restated Omnibus Incentive Plan (the “2014 Amended and Restated Plan”) which replaced the 2014 Omnibus Incentive Plan in its entirety.
On September 29, 2023, the Board and holders of a majority of the voting power of the outstanding capital stock of the Company adopted and approved Amendment No. 1 to the 2014 Amended and Restated Plan. Amendment No. 1 to the 2014 Amended and Restated Plan became effective on November 6, 2023.
On October 22, 2024, the second amendment and restatement of the Company's 2014 Amended and Restated Plan was approved to increase the number of shares of the Company's common stock issuable to 191,957, extend the expiration date of the plan to September 10, 2034, update the name of the plan to the “Skye Bioscience, Inc. Amended and Restated Omnibus Incentive Plan” and make certain administrative amendments (as so amended and restated, the "Amended and Restated Plan").
At the Company's 2026 Annual Meeting of Stockholders held on May 26, 2026, the Company's stockholders approved an amendment to the Company's Articles of Incorporation to increase the number of authorized shares of the Company's common stock from 12,500,000 shares to 37,500,000 shares (after giving effect to the August 2026 Reverse Stock Split). The Certificate of Amendment became effective upon its filing with the Nevada Secretary of State on May 28, 2026. This amendment did not modify the terms of the Amended and Restated Plan or increase the number of shares authorized for issuance under the Amended and Restated Plan.
As of September 30, 2026, the Company had 52,738 shares (after giving effect to the August 2026 Reverse Stock Split) available for future grant under the Amended and Restated Plan.
2024 Inducement Equity Incentive Plan
On July 2, 2024, the Board adopted the Skye Bioscience, Inc. 2024 Inducement Equity Incentive Plan (the "Inducement Plan"). The Company has reserved 75,000 shares of the Company’s common stock (after giving effect to the August 2026 Reverse Stock Split) for issuance pursuant to awards granted under the Inducement Plan. As of September 30, 2026, the Company had 69,063 shares (after giving effect to the August 2026 Reverse Stock Split) available for future grant under the Inducement Plan.
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Stock Options
The following is a summary of option activity under the Company’s Amended and Restated Plan and the Inducement Plan, for the nine months ended September 30, 2026:
Number of
Shares
Weighted
Average
Exercise Price
Weighted
Average
Remaining
Contractual
Term (Years)
Aggregate Intrinsic Value*
Outstanding, December 31, 2025566,041 $45.89 8.73$— 
Granted175,971 6.51 
Exercised— — 
Cancelled(35,449)44.46 
Forfeited(132,133)24.76 
Outstanding, September 30, 2026574,430$17.48 2.81$— 
Exercisable, September 30, 2026381,868$23.13 3.23$— 
*The aggregate intrinsic value is the sum of the amounts by which the quoted market price of the Company’s stock exceeded the exercise price of the stock options at September 30, 2026 for those stock options for which the quoted market price was in excess of the exercise price ("in-the-money options").
The weighted-average grant-date fair value of stock options granted during the nine months ended September 30, 2026, was $4.96.
The fair value of each stock option grant was estimated on the date of grant using the Black-Scholes option-pricing model under the following assumptions:
Nine Months Ended
September 30,
20262025
Dividend yield0.00%0.00%
Volatility
84.61 - 86.16%
83.86 - 85.93%
Risk-free interest rate
3.78- 4.00%
3.87 - 4.27%
Expected term (years)
5.27- 6.08
5.27 - 6.08

On March 31, 2026, the Company effected a stock option repricing (the “Option Repricing”) of all outstanding stock options held by current full-time employees, including the Company's executive officers, that were granted prior to December 31, 2025, under either the Amended and Restated Plan or the Inducement Plan. Pursuant to the Option Repricing, the exercise price of each repriced option was reduced to $4.9168 per share (or $0.6146 per share prior to giving effect to the 2026 Reverse Stock Split), the closing price per share of the Company’s common stock on the repricing date. No additional changes were made to the repriced options other than a reduction in the applicable exercise price. This was deemed a type I modification (probable to probable). The total incremental expense was $339,063, to be recognized over the remaining service period.
During the three months ended September 30, 2026, the Company accelerated vesting of stock options related to a group of employees which were then terminated. The total incremental compensation cost from the acceleration of these awards was equal to $743,716, related to an acceleration of a total of 147,250 options.
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Restricted Stock Units
The following is a summary of restricted stock unit ("RSU") activity during the nine months ended September 30, 2026:
Number of
Shares
Weighted
Average Grant Date Fair Value
Unvested, December 31, 202561,552 $77.76 
Granted136,250 4.16 
Vested(1,172)60.48 
Unvested, September 30, 2026196,630$26.86 
On August 7, 2026, the Company granted its CEO, Punit Dhillon, 136,250 restricted stock units.
2022 Employee Stock Purchase Plan
In June 2022, the Board approved the 2022 Employee Stock Purchase Plan (the "ESPP"), under which the Company may offer eligible employees the option to purchase common stock at a 15% discount to the lower of the market value of the stock at the beginning or end of each participation period under the terms of the ESPP. Total individual purchases in any year are limited to 15% of compensation. The ESPP was approved by the Company's stockholders on September 30, 2022. As of September 30, 2026, 1,050 shares (after giving effect to the 2026 Reverse Stock Split) shares were issued under the ESPP.
Stock-Based Compensation Expense
The Company recognizes stock-based compensation expense using the straight-line method over the requisite service period or derived service period. The Company recognized stock-based compensation expense for the stock options, ESPP, and the RSUs discussed above, in its unaudited condensed consolidated statements of operations as follows:
Three Months Ended
September 30,
Nine Months Ended
September 30,
2026202520262025
Research and development$1,135,283 $550,491 $2,214,007 $1,559,097 
General and administrative662,732 1,363,645 2,352,207 4,590,057 
$1,798,015 $1,914,136 $4,566,214 $6,149,154 
The total amount of unrecognized compensation cost was $5,067,012 as of September 30, 2026. This amount will be recognized over a weighted average period of 1.13 years.

8. Debt
Insurance premium loan payable
On February 1, 2026, the Company entered into an annual financing arrangement for a portion of its Directors and Officers Insurance Policy (the “D&O Insurance”) with First Insurance Funding whereby the Company borrowed $321,863. The loan is payable in equal monthly installments of $35,763, matures on October 13, 2026, and bears an interest at a rate 4.10% per annum. As of September 30, 2026, a total of $120,599 and $35,763, remained financed in prepaid expenses and insurance premium loan payable, respectively. The loan was repaid in full at maturity on October 13, 2026.

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9. Income (Loss) Per Share of Common Stock
The following tables are a reconciliation of the numerators and denominators used in the calculation of basic and diluted net income (loss) per share computations after adjusting for the 2026 Reverse Stock Split:
Three Months Ended
September 30,
Nine Months Ended
September 30,
2026202520262025
Basic EPS and diluted EPS:
Income (Loss) (Numerator)
Net income (loss)$69,126 $(12,754,660)$(23,226,829)$(41,482,851)
Shares (Denominator)
Basic weighted average common shares outstanding **4,960,912 4,958,241 4,960,656 4,956,814 
Dilutive impact of outstanding equity awards33,639 — — — 
Diluted weighted average common shares outstanding4,994,551 4,958,241 4,960,656 4,956,814 
Per-Share Amount (Basic)$0.01 $(2.57)$(4.68)$(8.37)
Per-Share Amount (Diluted)$0.01 $(2.57)$(4.68)$(8.37)
** The denominator considers the outstanding pre-funded warrants as common stock equivalents in calculating weighted average common shares outstanding.
For the three months ended September 30, 2026, performance stock units increased diluted weighted-average common shares outstanding by 33,639 shares, as determined under the treasury stock method. The awards had no effect on the numerator used to calculate diluted earnings per share.
The following outstanding shares of common stock equivalents were excluded from the computation of diluted net income (loss) per share of common stock for the periods presented because including them would have been anti-dilutive or the applicable vesting conditions had not been satisfied:
Three Months Ended
September 30,
Nine Months Ended
September 30,
2026202520262025
Stock options574,430 585,324 574,430 585,324 
Warrants333,211 386,148 333,211 386,148 
Unvested restricted stock units136,250 62,303 196,630 62,303 
10. Commitments and Contingencies
General Litigation and Disputes
From time to time, in the normal course of operations, the Company may be a party to litigation and other dispute matters and claims. Litigation can be expensive and disruptive to normal business operations. Moreover, the results of complex legal proceedings are difficult to predict. An unfavorable outcome to any legal matter, if material, could have a materially adverse effect on the Company’s operations or financial position, liquidity or results of operations.
Wendy Cunning vs Skye Bioscience, Inc.
The Company is a party to a legal proceeding with a former employee alleging, among other things, wrongful termination, violation of whistleblower protections under the Sarbanes-Oxley Act of 2002, and retaliation under California law against the Company relating to certain actions and events that occurred with the Company's former management during the employee's employment term from March 2018 to July 2019. The complaint seeks unspecified economic and non-economic losses, as well as attorneys’ fees. The case, entitled Wendy Cunning vs Skye Bioscience, Inc., was filed in U.S. District Court (the "District Court") for the Central District of California (the “Cunning Lawsuit”). On January 18, 2023, a jury rendered a verdict in favor of the plaintiff and awarded her $512,500 in economic damages (e.g., lost earnings, future earnings and interest), $840,960 in non-economic damages (e.g., emotional distress) and $3,500,000 in punitive damages. On August 2, 2023, the District Court ruled on the plaintiff's motion for attorney fees and awarded the plaintiff $1,200,008. Based on this order, the Company reduced
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the aggregate estimate for the legal contingency by $151,842, the difference between the attorney fees awarded by the District Court and the Company's previous estimate. On August 17, 2023, the Company obtained a stay on enforcement of the judgment in the Cunning Lawsuit by posting an appeal bond in the amount of $9,080,202.
In March of 2023, the Company appealed the judgment in the Cunning Lawsuit to the United States Court of Appeals for the Ninth Circuit (the "Ninth Circuit"). On October 22, 2024, the Ninth Circuit issued its decision in the Company's favor which vacated the judgment and remanded the case back to the District Court for a new trial. As a result, the Company recovered the $9,080,202 restriction on its cash related to the bond during the year ended December 31, 2024. The new trial commenced on November 3, 2026. On November 10, 2026, a jury returned a unanimous verdict of no liability in favor of the Company on all claims. The Company expects the judgement by the District Court will be entered in due course. See Note 12, Subsequent Events.
During the year ended December 31, 2024, management revised its assumptions related to its estimate of the legal contingency and the Company reversed the accrued interest on the original judgment and recognized a gain of $4,234,717 in change in estimate for legal contingencies. During the nine months ended September 30, 2026, management reassessed its estimate of the legal contingency based on developments in the litigation and information available through September 30, 2026. These developments included ongoing settlement discussions, the approaching retrial, and updated assessments regarding potential damages and litigation risk. Based on this reassessment, the Company increased its estimated legal contingency. As of September 30, 2026, the estimated legal contingency is $0, excluding accrued legal expenses. The decrease in the estimated legal contingency during the three months ended September 30, 2026 resulted in the recognition of a $5,000,000 change in estimate for legal contingencies in the accompanying unaudited condensed consolidated statements of operations. The decrease in the estimated legal contingency during the nine months ended September 30, 2026 resulted in the recognition of a $1,750,000 change in estimate for legal contingencies in the accompanying unaudited condensed consolidated statements of operations.
In reassessing the estimated legal contingency as of September 30, 2026, management considered the following factors:
•advice from external advisors, including its technical accounting advisors, regarding the appropriate application of GAAP, and legal counsel’s advice;
•the verdict returned on November 10, 2026 following the new trial, in which the jury unanimously found that the plaintiff did not engage in protected activity under the Sarbanes-Oxley Act of 2002 or the California whistleblower protection statute and awarded no damages, which management considered to provide additional evidence about conditions that existed as of September 30, 2026;
•the plaintiff’s ability to file post-trial motions and to appeal any judgment entered on the verdict, and legal counsel’s assessment of the likelihood that any such motion or appeal would succeed;
•the procedural posture of the litigation, including the Ninth Circuit’s vacatur of the prior judgment and remand for a new trial; and
•the Company’s possible defenses and counterclaims.

Based on these factors, management concluded that a loss in the Cunning Lawsuit is no longer probable and reduced the estimated legal contingency by $5,000,000 as of September 30, 2026. The remaining balance of $222,839 consists of accrued legal expenses incurred through September 30, 2026, which remain payable and are classified as Other current liabilities on the accompanying unaudited condensed consolidated balance sheets.

The plaintiff may file post-trial motions and may appeal any judgment entered on the verdict. The Company cannot predict whether the plaintiff will do so or the outcome of any such motion or appeal. If a post-trial motion or appeal were successful, the Company could be required to record a loss in a future period, and the amount of any such loss could be material. The Company intends to pursue all recoverable legal expenses related to the trial, however there is no assurance whether, or to what extent, these efforts will be successful.

Securities Class Action and Derivative Lawsuit
On November 17, 2025, a putative securities class action, Stout v. Skye Bioscience, Inc., et al., Case No. 3:25-cv-03177-WQH-DEB, was filed in the United States District Court for the Southern District of California. The action, as amended, asserts claims against the Company, its Chief Executive Officer and other defendants under Sections 10(b) and 20(a) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and SEC Rule 10b-5, based on allegations relating to the Company’s statements about its drug candidates, NB1111 (reference to former glaucoma program) and nimacimab, and to alleged trading in the Company’s securities, and seeks unspecified damages. On November 6, 2026, the parties entered into a stipulation of settlement, which does not include any admission of liability, providing for an aggregate cash payment of $2.5 million in
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exchange for releases of claims related to the action. The Company expects the settlement payment to be funded by its insurance carriers. The lead plaintiff has filed an unopposed motion for preliminary approval of the settlement. The proposed settlement remains subject to court approval and other customary conditions and is not final.

On January 29, 2026 and May 1, 2026, respectively, stockholders filed putative derivative actions captioned Domulot v. Dhillon, et al., Case No. 3:26-cv-00600-WQH-DEB, and White v. Dhillon, et al., Case No. 3:26-cv-02776-H-MSB, in the United States District Court for the Southern District of California. The actions assert claims, purportedly on behalf of the Company, which is named as a nominal defendant, against certain current and former officers and directors for breach of fiduciary duty, unjust enrichment, abuse of control, gross mismanagement, waste of corporate assets, violations of Section 14(a) of the Exchange Act and contribution under the Exchange Act, based on allegedly false or misleading statements concerning nimacimab. The complaints seek unspecified damages, attorneys’ fees and expenses, corporate governance reforms and other relief. The individual defendants deny the allegations. Both actions have been stayed pending developments in the securities class action. On August 11, 2026, the parties filed a joint motion to consolidate the actions, which the court granted on November 9, 2026.

On October 28, 2026, a third putative derivative action, Russo v. Dhillon, et al., Case No. 3:26-cv-06142-H-SBC, was filed in the United States District Court for the Southern District of California, asserting similar claims against certain current and former officers and directors. On November 3, 2026, the plaintiff voluntarily dismissed the action without prejudice and stated that she intends to pursue substantially similar claims in Nevada in accordance with the forum-selection provision in the Company’s amended and restated articles of incorporation. On November 9, 2026, the plaintiff filed a new action in the Eighth Judicial District Court in Clark County, Nevada, captioned Russo v. Dhillon, et al., Case No. A-26-961452-B.

11. Segment Reporting
The Company operates in one business segment, which includes the business of research and development activities related to developing medicine for obesity and other metabolic diseases. The determination of a single business segment is consistent with the consolidated financial information regularly provided to the Company’s chief operating decision maker (“CODM”). The Company’s CODM is its Chief Executive Officer, who reviews and evaluates consolidated net loss for purposes of assessing performance, making operating decisions, allocating resources, and planning and forecasting for future periods.
In addition to the significant expense categories included within consolidated net loss presented on the Company's Consolidated Statements of Operations, see below for disaggregated amounts that comprise research and development expenses which are presented to the Company's CODM for review:

Three Months Ended September 30,Nine Months Ended September 30,
2026202520262025
External clinical development expenses (1)
SBI-100
$— $8,270 $— $10,511 
nimacimab
(12,455)6,889,4837,029,38223,528,123
Total External clinical development expenses
(12,455)6,897,7537,029,38223,538,634
Personnel related and stock-based compensation
1,293,6361,495,8894,650,7494,241,662
Other research and development expenses (2)
35,041963,8021,513,7033,112,158
Total research and development expenses
$1,316,222 $9,357,444 $13,193,834 $30,892,454 
(1) External clinical development expenses include expenses for clinical trial costs and clinical manufacturing.
(2) Other research and development expenses include expenses for travel and entertainment, consulting and advisory, discovery research and development, and general business expenses.
The net book value of property and equipment in the US was equal to $20,430 and $55,488 for September 30, 2026, and December 31, 2025, respectively. The net book value of property and equipment outside of the US was equal to $0, and $843,442 for September 30, 2026, and December 31, 2025, respectively.

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12. Subsequent Events

The Company has evaluated subsequent events through the date on which these unaudited condensed consolidated financial statements were issued.

Cunning Lawsuit
On November 10, 2026, following the retrial of the case entitled Wendy Cunning vs. Skye Bioscience, Inc. in the U.S. District Court for the Central District of California, the jury returned a unanimous verdict in favor of the Company on all claims. The Company expects the judgment by the District Court will be entered in due course. The plaintiff may file post-trial motions and may appeal any judgment entered on the verdict. The Company cannot predict whether the plaintiff will do so or the outcome of any such motion or appeal.
The verdict provided additional evidence about conditions that existed as of September 30, 2026. Accordingly, the Company reduced the estimated legal contingency by $5,000,000 as of September 30, 2026, and recognized a corresponding reduction in change in estimate for legal contingencies in the accompanying unaudited condensed consolidated statements of operations for the three and nine months ended September 30, 2026. As of September 30, 2026, the remaining accrual of $222,839 relates to accrued legal expenses, which remain payable and are classified as Other current liabilities on the accompanying unaudited condensed consolidated balance sheets. See Note 10, Commitments and Contingencies.
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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations.
The following discussion and analysis of our financial condition and results of operations should be read in conjunction with our condensed consolidated financial statements (unaudited) for the three and nine months ended September 30, 2026 and 2025, together with the notes thereto and the consolidated financial statements and the related notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2025, which was filed with the SEC on March 10, 2026.
Solely for convenience, certain trademark and service marks (the “marks”) referred to in this Quarterly Report on Form 10-Q
appear without the ® or ™ symbols, but those references are not intended to indicate, in any way, that we will not assert, to
the fullest extent under applicable law, our rights to these marks.
Unless otherwise provided in this Quarterly Report on Form 10-Q, references to “we,” “us,” “our” and “Skye” in this discussion and analysis refer to Skye Bioscience, Inc., a Nevada corporation, together with its consolidated subsidiaries.
Overview
Our lead product candidate, nimacimab, a peripherally restricted negative allosteric modulating antibody targeting cannabinoid receptor 1 ("CB1")—a key GPCR involved in metabolic regulation that was developed as a subcutaneous injectable for the treatment of obesity and overweight. In the second quarter of 2026, we terminated the CBeyond trial and paused all research and development activities for nimacimab.

Results of CBeyond Phase 2a Proof-of-Concept Trial
We conducted CBeyondTM, a Phase 2a proof-of-concept clinical trial of nimacimab administered as a subcutaneous injectable for the treatment of obesity and overweight in the United States. The randomized, placebo- and active-controlled, double-blind CBeyond Phase 2a trial enrolled 136 adults with obesity or overweight, including individuals with a BMI ≥27 kg/m² with at least one comorbidity. Patients were randomized across four arms, 2:2:1:1 to arms with weekly nimacimab 200 mg subcutaneously, placebo, nimacimab 200 mg plus semaglutide (Wegovy®), or placebo plus semaglutide, and were dosed weekly for 26 weeks. Patients not participating in a 26-week extension were monitored for 13 weeks post-treatment.
In October 2025, we announced topline results from our CBeyond Phase 2a proof-of-concept clinical trial of nimacimab administered as a subcutaneous injectable for the treatment of obesity and overweight in the United States. Nimacimab monotherapy arm did not achieve the primary endpoint of weight loss compared to placebo (-1.52% vs. -0.26 for placebo, mITT). Preliminary pharmacokinetic analysis suggested an association between exposure and response, indicating that the 200 mg, subcutaneous weekly dose was suboptimal as a monotherapy. At the tested dose and exposure levels, nimacimab 200 mg demonstrated a favorable safety profile with placebo-like tolerability. In combination with semaglutide, there was no increase in gastrointestinal (GI) adverse events. Importantly, there were no increases in neuropsychiatric adverse events reported resulting from treatment with nimacimab. In the combination arm, nimacimab 200 mg, subcutaneous weekly dose plus semaglutide demonstrated a clinically meaningful magnitude of weight loss compared to semaglutide alone (-13.2% vs -10.25%, p=0.0372, mITT), with no plateau being observed through Week 26.
Patients who completed 26 weeks of treatment in the Phase 2a study were eligible to enroll in a 26-week extension for a potential full treatment duration of 52 weeks with a 13-week follow-up period. A total of 43 patients were enrolled, with 19 and 24 patients in the combination and monotherapy cohorts, respectively. In the combination arms, continued with blinded treatment with nimacimab or placebo and continued receiving semaglutide (Wegovy®). Patients in the monotherapy arm received nimacimab 300 mg during the extension.
19 participants in the combination cohorts completed week 26 were eligible for, and enrolled in the extension study. Seven participants in the combination group completed the additional 26 weeks of treatment lost an additional 7.9% of weight, resulting in a mean weight loss of 22.3% . According to initial results in this limited cohort, the combination therapy remained safe and well tolerated. No SAEs or AESIs were reported during the extension period. Moreover, the 7 participants in the semaglutide-alone group completed treatment of the additional 26 weeks and lost an additional 5.8% of weight during the extension period, resulting in a mean weight loss of 19.7%. Following termination of the CBeyond trial, the Company does not expect to report additional data from the extension period, including nimacimab monotherapy data and 13-week off-therapy follow-up data.
We believe multiple factors may have resulted in the lower than anticipated weight loss results for nimacimab as a monotherapy, including a lower systemic exposure than originally modeled, and a better understanding of tissue exposure required to drive weight loss with peripheral CB1 inhibition.
In March 2026, we initiated an expansion study (Part C) of the CBeyond Phase 2a trial to assess preliminary safety and pharmacokinetic (PK) profile of nimacimab administered intravenously (IV). The expansion study comprised of two cohorts of nimacimab monotherapy (400 mg IV and 600 mg IV) compared to placebo administered weekly over 15 weeks (16 doses), with
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a 12 week follow up period, to generate preliminary monotherapy safety, PK, and exploratory efficacy data. Each dose cohort was designed to randomize 8 participants in a 3:1 ratio to nimacimab (n=6) or placebo (n=2). Eight (8) participants were randomized in the first cohort, and the last participant was dosed on May 28, 2026, before completion of the planned treatment period. No participants were enrolled in the second cohort before the Company terminated the study.
On May 20, 2026 we announced that the Cohort Review Committee (CRC) responsible for reviewing safety data generated from the CBeyond Part C Expansion Study, and for approving the opening of enrollment in Cohort 2 has unanimously approved opening the second cohort of the CBeyond Part C Expansion study. On May 29, 2026, before any participant was enrolled in the second cohort, the Company terminated the CBeyond trial, including the Part C expansion study.

Recent Developments
Termination of CBeyond Study
With recent approvals of oral versions of GLP-1 receptor agonists (WEGOVY and FOUNDAYO), combined with continued development GLP-1, GIP, glucagon triple agonists, such as retatrutide demonstrating greater than 25% weight loss, Skye management determined that nimacimab's current target product profile which included at least a 600mg once-weekly dose, or 6 mL weekly injection, may not significantly penetrate the increasingly competitive anti-obesity medicine market. As a result, the Company terminated all clinical activities related to CBeyond, including enrollment for the CBeyond expansion (Part C) study, and paused all R&D activities associated with nimacimab in order to evaluate strategic options. In addition, the Company instituted multiple cost-cutting measures, including but not limited to, a reduction in workforce and termination of certain vendor contracts and licensing agreements.
Transaction with Redx Pharma Limited
On August 14, 2026, we entered into the Transaction Agreement with Redx. Pursuant to the Transaction Agreement, and subject to the terms and conditions set forth therein, we will acquire the entire issued and to be issued share capital of Redx pursuant to a Scheme of Arrangement. Upon the consummation of the Transaction, the combined company will be led by the Redx management team and plans to operate under the name Fibrx Therapeutics, Inc. The Transaction Agreement was unanimously approved by the Board and is subject to certain customary closing conditions, including the approval by the stockholders of each company. See Note 2, Pending Redx Transaction and Related Financings, in the accompanying unaudited condensed consolidated financial statements, for additional information.
Skye Contingent Value Rights Agreement
Immediately prior to the Effective Time, the Company and a rights agent are expected to enter into the Skye CVR Agreement, pursuant to which holders of record of common stock as of the close of business on the last business day prior to the day on which the Effective Time occurs will receive one Skye CVR for each outstanding share of common stock held as of such date. Pursuant to the Skye CVR Agreement, each Skye CVR holder will be entitled to receive their pro rata share of an aggregate cash payment equal to 90% of the net proceeds, if any, received by the combined company as a result of the Skye CVR Payments made to the combined company of any upfront, milestone, royalty and other payments received under any disposition agreement related to certain of the Company’s pre-Transaction assets (the “Legacy Assets”). In the event that no such proceeds are received during the CVR Term (as defined in the Skye CVR Agreement), holders of the Skye CVRs will not receive any payment pursuant to the Skye CVR Agreement. There can be no assurance that any Skye CVR holders will receive any Skye CVR Payments. The right to the contingent payments contemplated by the Skye CVR Agreement is a contractual right only and is not transferable, except in the limited circumstances specified in the Skye CVR Agreement.
Redx Contingent Value Rights Agreement
Immediately prior to the Effective Time, Redx and a rights agent are expected to enter into the Redx CVR Agreement, pursuant to which holders of record of Redx ordinary shares as of the close of business on the last business day prior to the day on which the Effective Time occurs will receive one Redx CVR for each outstanding Redx ordinary share held as of such date. Pursuant to the Redx CVR Agreement, each Redx CVR holder will be entitled to receive, in the form of shares of Redx CVR Stock, their pro rata share of an aggregate cash payment equal to 100% of the net proceeds, if any, received by the Company as a result of payments made to the Company of any upfront, milestone, royalty and other payments received under any disposition agreement related to certain of Redx’s pre-Transaction assets. The Redx CVR Stock, if any, will become issuable for subsequent delivery by the rights agent to the Redx CVR holders. In the event that no such proceeds are received during the term of the Redx CVR Agreement, holders of the Redx CVRs will not receive any deliveries pursuant to the Redx CVR Agreement. There can be no assurance that any Redx CVR holders will receive any Redx CVR Stock. The right to the
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contingent payments contemplated by the Redx CVR Agreement is a contractual right only and is not transferable, except in the limited circumstances specified in the Redx CVR Agreement.
Concurrent Financing
Concurrently with entering into the Transaction Agreement, we entered into the PIPE Securities Purchase Agreement the Investors. Pursuant to the PIPE Securities Purchase Agreement, and subject to the terms and conditions therein, the Company agreed to sell, and the Investors agreed to purchase, immediately after the Closing, shares of common stock for an aggregate purchase price of $67.9 million, which may increase to up to $72.9 million, subject to certain conditions. The closing of the Concurrent Financing is anticipated to occur immediately after the Closing on the Closing Date, subject to the satisfaction of customary closing conditions.
Additionally, concurrently with entering into the Transaction Agreement, Redx entered into subscription agreements with new and existing Redx investors, including Redx's existing major shareholder, Redmile, pursuant to which, on August 27, 2026, Redx issued Series A Shares in the capital of Redx for an aggregate purchase price of $36.0 million (the Series A Financing, together with the Concurrent Financing, the “Financing”), which Series A Shares form part of the Scheme Shares. The Financing is expected to provide the combined company with an aggregate total gross proceeds of approximately $103.9 million, which may increase to up to $108.9 million, subject to certain conditions set forth in the Side Letter. See Note 2, pending Redx Transaction and Related Financings, for additional information.
Equity Line of Credit and Warrant
On August 21, 2026, Skye entered into the ELOC Securities Purchase Agreement with Buyer, providing for the ELOC of up to $22.0 million, subject to certain conditions and limitations. The available ELOC amount will be reduced to the extent aggregate proceeds from the Financing exceed $103.0 million and eliminated entirely if such proceeds reach $125.0 million. As of August 14, 2026, investors had committed $67.9 million under the PIPE Securities Purchase Agreement, which may increase to up to $72.9 million under the Side Letter, and Redx had raised $36.0 million in the Series A Financing. To the extent aggregate Financing proceeds are less than $125.0 million, the Company may be required to sell shares to Buyer under the ELOC, subject to its terms and conditions, which would result in additional dilution. There can be no assurance that additional investment commitments will be obtained In connection with the ELOC, Skye agreed to issue a warrant to Buyer to purchase up to $5.0 million of common stock and/or Non-Voting Common Stock upon the Closing. The number of shares underlying the Warrant will be determined by dividing $5.0 million by the price per share of common stock paid by the Investors pursuant to the PIPE Securities Purchase Agreement. The Warrant will be issued regardless of whether any shares are purchased under the ELOC.
Termination of Halozyme License Agreement
In December 2025, the Company entered into a Non-exclusive Global Collaboration and License Agreement (the “Halozyme License Agreement”) with Halozyme, Inc. (“Halozyme”).
Under the terms of the Halozyme License Agreement, Halozyme granted the Company a non-exclusive license to Halozyme’s ENHANZE® drug delivery technology for the development of a subcutaneous co-formulation with nimacimab (such combination, the “Product”). Halozyme will also be the Company’s exclusive supplier of clinical and commercial supplies of the active pharmaceutical ingredient ("API") for Halozyme’s rHuPH20 bulk drug product.
On August 11, 2026, the Company notified Halozyme of its intent to terminate the Halozyme License Agreement.

Cunning Lawsuit

On November 10, 2026, following the retrial of Wendy Cunning vs. Skye Bioscience, Inc. in the U.S. District Court for the Central District of California, the jury returned a unanimous verdict in favor of the Company on all claims. The Company expects the judgement by the District Court will be entered in due course. The plaintiff may file post-trial motions and may appeal any judgment entered on the verdict. The Company cannot predict whether the plaintiff will do so or the outcome of any such motion or appeal. See Note 12, Subsequent Events, to the accompanying unaudited condensed consolidated financial statements.
Financial Overview
Revenues
To date, we have not commercialized any products and have never generated revenue from the commercialization of any product. If we are unable to complete the proposed Transaction, we may need to raise additional capital. There can be no assurances, however, that additional funding will be available on terms acceptable to us, or at all.
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Research and Development Expenses
During the three and nine months ended September 30, 2026, we incurred $1,316,222 and $13,193,834 in research and development expenses, respectively. Third-quarter expenses consisted primarily of personnel-related costs, including stock-based compensation from the accelerated vesting of options held by terminated employees. Nine-month expenses related primarily to the CBeyond trial and its termination.
During the three and nine months ended September 30, 2025, we incurred $9,357,444 and $30,892,454 in research and development expense, respectively, primarily related to our efforts in conducting our Phase 2a clinical trial related to our Phase 2a clinical trial for nimacimab for obesity.
As a result of terminating the CBeyond trial and any other research and development expenses associated with nimacimab, including workforce reduction, vendor contracts and license agreements, we expect research and development expenses in the future will be significantly reduced until the completion of the proposed Transaction.
General and Administrative Expenses
Our general and administrative expenses have fluctuated year-over-year as we have entered into various strategic acquisitions to restructure and reposition our company. Additionally, as a business in the early stages of drug development we are continually evaluating our operations and infrastructure to identify areas where we can increase efficiencies. As a public company, we expect to incur additional expenses related to insurance, investor relations activities, legal and other administration and professional services to comply with the rules and regulations of the SEC, the Financial Industry Regulatory Authority ("FINRA") and Nasdaq. Other significant costs are expected to include legal fees relating to patent and corporate matters, business development costs and fees for consulting services. To incentivize our employees and be competitive to retain strong talent we issued additional equity awards in 2026 and 2025 and we repriced certain options in the first quarter of 2026, which have resulted in increased stock-based compensation expense. We expect general and administrative expenses to reduce in the future resulting from workforce reduction activities and will continue to reduce until the proposed Transaction is complete.
Estimate for Legal Contingencies and Related Expenses
The estimate for legal contingencies and related expenses relates to a litigation matter that related to a former employee of the Company. As of December 31, 2023, we had posted an appellate bond that was collateralized by an irrevocable letter of credit equal to, $9,080,202, approximately 150% of the liability recorded on our balance sheet. As of December 31, 2024, we were successful in our appeal of the judgment in the Ninth Circuit Court of Appeals and the case was remanded back to the District Court for a new trial, as a result of which we recovered the appellate bond and reduced the estimated legal contingency based on new key assumptions. For the three months ended September 30, 2026, we recorded a $5,000,000 reduction in the estimated legal contingency from the reversal of the Cunning Lawsuit loss accrual. The November 10, 2026 jury verdict provided additional evidence about conditions existing as of September 30, 2026. For the nine months ended September 30, 2026, the reversal more than offset the $3,250,000 increase recorded in the second quarter, resulting in a net credit of $1,750,000. See Note 10, Commitments and Contingencies and Note 12, Subsequent Events to the accompanying unaudited condensed consolidated financial statements.
Other (Income) Expense
Other (income) expense primarily includes interest income earned on our cash and cash equivalent balances and short term investments.
Critical Accounting Estimates
There have been no material changes in our Critical Accounting Estimates from the information provided in the "Critical Accounting Estimates" section of "Item 7- Management's Discussion and Analysis of Financial Condition and Results of Operations" in our Annual Report on Form 10-K for the fiscal year ended December 31, 2025.
Recently Issued and Adopted Accounting Pronouncements
See Note 1 to the accompanying unaudited condensed consolidated financial statements included in Part I, Item 1 of this Quarterly Report on Form 10-Q for information on recently issued accounting pronouncements and recently adopted accounting pronouncements. While we expect certain recently adopted accounting pronouncements to impact our disclosures in future periods, the impact upon adoption was not significant to our current estimates and operations.
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Results of Operations
For the three months ended September 30, 2026 and 2025
Research and Development Expenses
Below is a summary of our research and development expenses during the three months ended September 30, 2026 and for the same period in 2025:
Three Months Ended September 30,
20262025$ Change
2026 vs. 2025
% Change
2026 vs. 2025
Research and development expenses$1,316,222 $9,357,444 $(8,041,222)(86)%
Research and development expenses for the three months ended September 30, 2026, decreased by $8,041,222 as compared to the same period in 2025. The net decrease in research and development expenses was primarily due to:
•Clinical trial costs decreased by $4,179,912 due to the termination of all clinical activities related to CBeyond, including enrollment for the CBeyond expansion (Part C) study, and the pausing of all R&D activities associated with nimacimab in order to evaluate strategic options.
•Contract manufacturing costs decreased by $2,720,237 due to the termination of all clinical activities related to CBeyond, including enrollment for the CBeyond expansion (Part C) study, and the pausing of all R&D activities associated with nimacimab in order to evaluate strategic options.
•Discovery research and development costs decreased $481,674 primarily due to the pausing of all R&D activities and cost-cutting measures implemented as the Company evaluates strategic options.
•Quality assurance costs decreased by $105,513 primarily due to the pausing of all R&D activities and cost-cutting measures implemented as the Company evaluates strategic options.
•Salaries and stock-based compensation decreased by $202,253 primarily due to a reduction in headcount, partially offset by the acceleration of vested options for terminated employees.
•Consulting, advisory and professional fees decreased by $374,969 primarily due to the pausing of all R&D activities associated with nimacimab and cost-cutting measures implemented as the Company evaluates strategic options.
General and Administrative Expenses
Below is a summary of our general and administrative expenses during the three months ended September 30, 2026, and for the same period in 2025:
Three Months Ended September 30,
20262025$ Change
2026 vs. 2025
% Change
2026 vs. 2025
General and administrative expenses$3,657,461 $3,907,090 $(249,629)(6)%
General and administrative expenses for the three months ended September 30, 2026, decreased by $249,629 as compared to the same period in 2025. The decrease in general and administrative expenses was primarily due to:
•Salaries, benefits and other direct employee related costs decreased by $1,229,387 primarily due to lower headcount.
•Consulting, advisory and professional fees increased by $392,808 primarily due to a $425,000 cash fee paid to Stifel for its fairness opinion obtained in connection with the Transaction, partially offset by an overall reduction in consulting services utilized during the period.
•Investor relations, marketing and communications expenses decreased by $211,670 primarily due to reductions in content creation and digital marketing expenses.
•Legal fees increased by $941,721 due to costs associated with the strategic alternatives process and negotiation of the proposed Transaction Agreement and litigation defense costs.
•General business expenses decreased by $143,101 primarily due to headcount reductions and associated travel and entertainment expenses, as compared to the same period in the prior year.
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Change in Estimate for Legal Contingencies
Total change in estimate for legal contingencies for the three months ended September 30, 2026, and for the same period in 2025:
Three Months Ended September 30,
20262025$ Change
2026 vs. 2025
% Change
2026 vs. 2025
Change in estimate for legal contingencies$(5,000,000)$— $(5,000,000)100 %
For the three months ended September 30, 2026, we recorded a $5,000,000 reduction in the estimated legal contingency based on the jury verdict in the retrial of the Cunning Lawsuit, which provided additional evidence about conditions that existed as of September 30, 2026. See Note 10, Commitments and Contingencies and Note 12, Subsequent Events to the accompanying unaudited condensed consolidated financial statements

Other (Income) Expense
Below is a summary of our other (income) expense for the three months ended September 30, 2026 and for the same period in 2025:
Three Months Ended September 30,
20262025$ Change
2026 vs. 2025
% Change
2026 vs. 2025
Interest expense$3,299 $— $3,299 100 %
Interest and other income, net(49,099)(418,474)369,375 (88)%
Gains from asset sales— (91,400)91,400 (100)%
Other expense2,991 — 2,991 100 %
Total other income$(42,809)$(509,874)$467,065 (92)%
For the three months ended September 30, 2026, other income decreased $467,065 as compared to the same period in 2025 primarily due to:
•Decreases in interest income and other income, net of $369,375 due to decreased interest from our cash equivalents and short-term investments yields as a result of the decrease in cash equivalents and short-term investments on hand.
For the nine months ended September 30, 2026 and 2025
Research and Development Expenses
Below is a summary of our research and development expenses during the nine months ended September 30, 2026 and for the same period in 2025:
Nine Months Ended September 30,
20262025
$ Change
2026 vs. 2025
% Change
2026 vs. 2025
Research and development expenses$13,193,834 $30,892,454 $(17,698,620)(57)%
Research and development expenses for the nine months ended September 30, 2026, decreased by $17,698,620 as compared to the same period in 2025. The net decrease in research and development expenses was primarily due to:
◦Clinical trial costs decreased by $6,017,332 due to the termination of all clinical activities related to CBeyond, including enrollment for the CBeyond expansion (Part C) study, and the pausing of all R&D activities associated with nimacimab in order to evaluate strategic options.
◦Contract manufacturing costs decreased by $10,402,172 due to the termination of all clinical activities related to CBeyond, including enrollment for the CBeyond expansion (Part C) study, and the pausing of all R&D activities associated with nimacimab in order to evaluate strategic options.
◦Discovery research and development costs decreased by $1,205,735 primarily due to the pausing of all R&D activities and cost-cutting measures implemented as the Company evaluates strategic options.
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◦Quality assurance costs decreased by $191,889 primarily due to the pausing of all R&D activities and cost-cutting measures implemented as the Company evaluates strategic options.
◦Salaries and stock-based compensation increased by $409,086 primarily due to the acceleration of vested options for terminated employees, offset by a reduction in headcount.
◦Consulting, advisory and professional fees decreased by $217,747 primarily due to the pausing of all R&D activities associated with nimacimab and cost-cutting measures implemented as the Company evaluates strategic options, partially offset from a build out of the Company's SOP system.
General and Administrative Expenses
Below is a summary of our general and administrative expenses during the nine months ended September 30, 2026, and for the same period in 2025:
Nine Months Ended September 30,
20262025$ Change
2026 vs. 2025
% Change
2026 vs. 2025
General and administrative expenses$12,265,518 $12,375,567 $(110,049)(1)%
General and administrative expenses for the nine months ended September 30, 2026, decreased by $110,049 as compared to the same period in 2025. The increase in general and administrative expenses was primarily due to:
◦Salaries, benefits and other direct employee related costs decreased by $2,921,051 primarily due to lower headcount.
◦Consulting, advisory and professional fees increased by $522,623 primarily due to a $425,000 cash fee paid to Stifel for its fairness opinion obtained in connection with the Transaction, and the timing of tax accounting services and financial advisory services.
◦Investor relations, marketing and communications expenses decreased by $759,056 primarily due to reductions in content creation and digital marketing expenses.
◦Recruiting fees decreased by $83,750 primarily due to the one time cost to hire an executive in the prior period.
◦Legal fees increased by $3,480,114 due to costs associated with the strategic alternatives process and negotiation of the proposed Transaction Agreement and litigation defense costs.
◦General business expenses decreased $348,929 primarily due to headcount reductions and associated travel and entertainment expenses, as compared to the same period in the prior year.
Change in Estimate for Legal Contingencies
Total change in estimate for legal contingencies for the nine months ended September 30, 2026, and for the same period in 2025:
Nine Months Ended September 30,
20262025$ Change
2026 vs. 2025
% Change
2026 vs. 2025
Change in estimate for legal contingencies$(1,750,000)$— $(1,750,000)100 %
For the nine months ended September 30, 2026, we recorded a $5,000,000 reduction in the estimated legal contingency based on the jury verdict in the retrial of the Cunning Lawsuit, which offset the $3,250,000 increase recorded in the second quarter, resulting in a net credit of $1,750,000. The November 10, 2026 jury verdict provided additional evidence about conditions existing as of September 30, 2026. See Note 10, Commitments and Contingencies and Note 12, Subsequent Events to the accompanying unaudited condensed consolidated financial statements
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Other (Income) Expense
Below is a summary of our other (income) expense for the nine months ended September 30, 2026 and for the same period in 2025:
Nine Months Ended September 30,
20262025
$ Change
2026 vs. 2025
% Change
2026 vs. 2025
Interest expense$8,797 $— 8,797 100 %
Interest and other income, net(321,922)(1,609,807)1,287,885 (80)%
Gains from asset sales(178,200)(180,763)2,563 (1)%
Other expense5,402 — 5,402 100 %
Total other income$(485,923)$(1,790,570)$1,304,647 (73)%
For the nine months ended September 30, 2026, other income decreased $1,304,647 as compared to the same period in 2025 primarily due to:
◦Decreases in interest income and other income, net of $1,287,885 due to decreased interest from our cash equivalents and short-term investments yields as a result of the decrease in cash equivalents and short-term investments on hand.
Liquidity, Going Concern and Capital Resources
Liquidity

We have incurred operating losses and negative cash flows from operations since our inception. We expect to continue to incur significant losses and negative cash flows from operations through 2026 and into the foreseeable future. Historically, we have funded our operations primarily through issuance of equity securities, borrowings from a related party and strategic transactions. We have not commercialized any products and have never generated revenue from the commercialization of any product. If we are unable to complete the proposed Transaction, we may need to raise additional capital. There can be no assurances, however, that additional funding will be available on terms acceptable to us, or at all.
As of September 30, 2026, we had working capital of $1,323,090, an accumulated deficit of $210,101,315, and stockholders’ equity of $1,360,409. We had unrestricted cash and cash equivalents in the amount of $4,815,851 as of September 30, 2026, as compared to unrestricted cash and cash equivalents and short-term investments in the amount of $25,737,221 as of December 31, 2025. For the three months ended September 30, 2026, the Company incurred income from operations of $26,317. For the three months ended September 30, 2025, the Company incurred loss from operations of $13,264,534. For the nine months ended September 30, 2026 and 2025, the Company incurred losses from operations of $23,709,352 and $43,268,021, respectively. For the three months ended September 30, 2026, the Company incurred net income of $69,126. For the three months ended September 30, 2025, the Company incurred net losses of $12,754,660. For the nine months ended September 30, 2026 and 2025, the Company incurred net losses of $23,226,829 and $41,482,851, respectively.
Going Concern
Our independent registered public accounting firm issued a report on our audited consolidated financial statements as of and for the year ended December 31, 2025, that included an explanatory paragraph expressing substantial doubt about our ability to continue as a going concern due to our recurring operating losses. Our condensed consolidated financial statements have been prepared on a going concern basis, which contemplates the realization of assets and settlement of liabilities in the normal course of business. Our accompanying condensed consolidated financial statements do not include any adjustments to the carrying amounts or classification of assets and liabilities that may be necessary should we be unable to continue as a going concern. Refer to "Risks Related to Our Limited Operating History, Financial Position and Capital Requirements — Our independent registered public accounting firm has expressed substantial doubt about our ability to continue as a going concern, and if we are unable to continue, you may lose your entire investment" in our Annual Report on Form 10-K for additional information.

As of September 30, 2026, we have substantially reduced operations including termination of the CBeyond trial, significant reduction of all R&D costs associated with the development of nimacimab and other potential pipeline assets, reduction in workforce, and termination of vendor contracts and licensing agreements.
Our future capital requirements will depend on many factors, including:
•Our ability to complete the proposed Transaction with Redx;
32


•the costs associated with being a public company;
•the amount of revenue, if any, received from the monetization of the Legacy Assets, commercial sales of our drug candidates, should any of our drug candidates receive marketing approval;
•the costs involved in preparing, filing, prosecuting, maintaining, defending and enforcing possible patent claims, including litigation costs and the outcome of any such litigation;
•the outcome of any post-trial motions or appeal in the litigation matter discussed above under “General Litigation and Disputes, Wendy Cunning vs. Skye Bioscience, Inc.” and “Financial Overview, Estimate for Legal Contingencies and Related Expenses”; and
•the impact of any of the foregoing of macroeconomic events, including inflation, fluctuating interest and exchange rates, and market volatility as a result of trade, fiscal and regulatory policies, including tariffs and any effects of a prolonged government shutdown.
Cash Flows
The following is a summary of our cash flows for the periods indicated and has been derived from our unaudited condensed consolidated financial statements which are included elsewhere in this Quarterly Report on Form 10-Q:
Nine Months Ended September 30,
20262025
Net cash used in operating activities$(20,811,169)$(33,296,042)
Net cash provided by (used in) investing activities20,033,773 (16,696,778)
Net cash (used in) provided by in financing activities(289,251)18,158 
Cash Flows from Operating Activities
The primary use of cash for our operating activities during the period was to fund research development activities for our clinical product candidate and general and administrative activities. Our cash used in operating activities also reflected changes in our working capital, net of adjustments for non-cash charges, such as stock-based compensation, depreciation and amortization.
Cash used in operating activities of $20,811,169 during the nine months ended September 30, 2026, reflected a net loss of $23,226,829, partially offset by aggregate non-cash charges of $3,603,363 and included a $1,187,703 net cash outflow in our operating assets and liabilities.
Non-cash charges included a $(1,750,000) change in estimate for legal contingencies, $4,566,214 for stock-based compensation expense primarily attributable to the recognition of current period expense on prior grants, $603,540 impairment and loss on disposal of property and equipment, and $361,809 in depreciation and amortization. The net change in our operating assets and liabilities included a $1,459,368 cash inflow from the decrease in our prepaid expenses and other current assets, a $3,278,052 net cash outflow from decrease in our accrued expenses and other current liabilities and a $415,013 cash inflow from the increase of our accounts payable.
Cash used in operating activities of 33,296,042 during the nine months ended September 30, 2025, reflected a net loss $41,482,851, partially offset by aggregate non-cash charges of $6,511,734 and included a $1,675,075 net cash outflow in our operating assets and liabilities.
Cash Flows from Investing Activities
During the nine months ended September 30, 2026, our cash provided by investing activities related primarily to the maturity, of $19,854,723 in short-term investments.
During the nine months ended September 30, 2025, our cash used in investing activities related primarily to the purchase of $16,871,229 in short-term investments and $180,763 in net proceeds from the sale of the AVI building.
Cash Flows from Financing Activities
During the nine months ended September 30, 2026, cash used in financing activities included $286,100 in repayments on the our insurance premium loan payable.
During the nine months ended September 30, 2025, cash provided by financing activities included $18,158 in proceeds from the purchase under employee stock purchase plan.
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Off-Balance Sheet Arrangements
There are no off-balance sheet arrangements that have or are reasonably likely to have a current or future effect on our financial condition, changes in financial condition, revenues or expenses, results of operations, liquidity, capital expenditures or capital resources that is material to investors.
Item 3. Quantitative and Qualitative Disclosures about Market Risk.
Not applicable.
Item 4. Controls and Procedures.
Evaluation of disclosure controls and procedures. We maintain controls and procedures that are designed to ensure that information required to be disclosed in the reports that we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms, and that such information is accumulated and communicated to our management, including our Chief Executive Officer, as appropriate, to allow timely decisions regarding required disclosures. In designing and evaluating the disclosure controls and procedures, management recognizes that any control and procedures, no matter how well designed and operated, can only provide reasonable assurance of achieving the desired control objectives, and in reaching a reasonable level of assurance, management necessarily is required to apply its judgement in evaluating the cost-benefit relationship of possible controls and procedures.
Management, under the supervision and with the participation of the Company’s Chief Executive Officer, who also serves as its principal financial and accounting officer, evaluated the effectiveness of the Company’s disclosure controls and procedures as of September 30, 2026. During the preparation and review of the financial statements included in this Quarterly Report, management identified a material weakness in the Company’s controls over stock-based compensation expense. Specifically, the Company did not maintain effective review controls to verify the completeness and accuracy of award data and related compensation expense calculations provided by its third-party stock administration service provider, including changes associated with employee terminations and award expirations. These deficiencies resulted in errors in reported award fair values and compensation expense. Based on this evaluation, management concluded that the Company’s disclosure controls and procedures were not effective at a reasonable assurance level as of September 30, 2026. Our remediation efforts with respect to this material weakness are continuing, and we have determined that this material weakness is continuing as of September 30, 2026.
Notwithstanding the identified material weakness, management has concluded that the condensed consolidated financial statements included in this Quarterly Report fairly present, in all material respects, our financial condition, results of operations and cash flows for the periods presented in conformity with GAAP.
Remediation Plans. Management, with the oversight of the Audit Committee of the Board of Directors have evaluated the impact of the material weakness describe above and designed a remediation plan to enhance our internal control environment. The identified errors were corrected before issuance of the financial statements included in this Quarterly Report. To remediate the material weakness, we plan to enhance the design, including the precision, of management’s review control over stock-based compensation expense, including the completeness and accuracy of award data and expense calculations received from our third-party stock administration service provider. In addition, we will retain incremental evidence of the execution of such procedures.
The identified errors were corrected before issuance of the financial statements included in this Quarterly Report in coordination with the Company’s third-party stock administration service provider and we are enhancing the Company’s quarterly review controls over stock-based compensation. These enhancements include documented reconciliations of award data to approved grant, modification and termination terms; review of changes processed by the service provider; and independent validation of compensation expense calculations for modified and terminated awards.
While we believe that this action will remediate the material weakness, we have not completed all of the corrective processes, procedures and related evaluation or remediation that we believe are necessary. As we continue to evaluate and work to remediate the material weakness, we may take additional measures to address the material weakness.
Until the remediation step set forth above, including the efforts to implement the necessary control activities we identify, are fully implemented and concluded to be operating effectively for a sufficient period of time, the material weakness described above will not be considered remediated.
Changes in internal controls. Except for the material weakness described above, there were no changes in internal control over financial reporting that occurred during the fiscal quarter covered by this report that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.
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PART II - OTHER INFORMATION
Item 1. Legal Proceedings
For a description of material legal proceedings, see Note 10, "General Litigation and Disputes" to the accompanying unaudited condensed consolidated financial statements included in this Quarterly Report on Form 10-Q.
Item 1A. Risk Factors.
There have been no material changes to the risk factors previously disclosed by us in Part I, Item 1A "Risk Factors" of our Annual Report on Form 10-K for the fiscal year ended December 31, 2025 filed with the SEC on March 10, 2026, and in Part II, Item 1A of our Quarterly Report on Form 10-Q for the quarter ended June 30, 2026 filed with the SEC on August 14, 2026.
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.
None.
Item 3. Defaults Upon Senior Securities.
None.
Item 4. Mine Safety Disclosures.
Not applicable.
Item 5. Other Information.
Rule 10b5-1 and Non-Rule 10b5-1 Trading Arrangements
No officers or directors, as defined in Rule 16a-1(f) under the Exchange Act, adopted and/or terminated a "Rule 10b5-1 trading arrangement" or a "non-Rule 10b5-1 trading arrangement," as defined in Regulation S-K Item 408, during the last fiscal quarter.
35


Item 6. Exhibits.
3.1
3.2
3.3
10.1#†
10.2#†
10.3#†
10.4#†
31.1#
31.2#
32.1#
32.2#
101#
The following materials from the Skye Biosciences, Inc. Quarterly Report on Form 10-Q for the quarter ended September 30, 2026, formatted in Inline Extensible Business Reporting Language (iXBRL): (i) Condensed Consolidated Balance Sheets (Unaudited), (ii) Condensed Consolidated Statements of Operations (Unaudited), (iii) Condensed Consolidated Statements of Cash Flows (Unaudited), (iv) Condensed Consolidated Statements of Stockholders’ Deficit (Unaudited), and (v) related Notes to the Unaudited Condensed Consolidated Financial Statements.
104Cover Page Interactive Data File (embedded within the Inline XBRL document)
_________
# Filed Herewith
† Management contract or compensatory plan or arrangement.
36


SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
Skye Bioscience, Inc.,
a Nevada corporation
November 13, 2026By:/s/ Punit Dhillon
Punit Dhillon
Its:Chief Executive Officer, President, Secretary and Director
(Principal Executive Officer & Principal Financial and Accounting Officer)

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