SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP


Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
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 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
  
 Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
5AM Partners VII, LLC
(Last) (First) (Middle)
501 2ND STREET, SUITE 350
(Street)
SAN FRANCISCO CA 94107
(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
Skye Bioscience, Inc. [ SKYE ] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director X 10% Owner
Officer (give title below) Other (specify below)
3. Date of Earliest Transaction (Month/Day/Year)
03/13/2024
4. If Amendment, Date of Original Filed (Month/Day/Year)
 6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
X Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 03/13/2024 P 450,000 A $10 8,393,520 I By 5AM Ventures VII, L.P.(1)
Common Stock 1,718,189 I By 5AM Ventures II, L.P.(2)
Common Stock 67,796 I By 5AM Co-Investors II, L.P.(3)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
1. Name and Address of Reporting Person*
5AM Partners VII, LLC
(Last) (First) (Middle)
501 2ND STREET, SUITE 350
(Street)
SAN FRANCISCO CA 94107
(City) (State) (Zip)
1. Name and Address of Reporting Person*
5AM Ventures VII, L.P.
(Last) (First) (Middle)
501 2ND STREET, SUITE 350
(Street)
SAN FRANCISCO CA 94107
(City) (State) (Zip)
1. Name and Address of Reporting Person*
5AM Partners II, LLC
(Last) (First) (Middle)
501 2ND STREET, SUITE 350
(Street)
SAN FRANCISCO CA 94107
(City) (State) (Zip)
1. Name and Address of Reporting Person*
5AM Ventures II LP
(Last) (First) (Middle)
501 2ND STREET, SUITE 350
(Street)
SAN FRANCISCO CA 94107
(City) (State) (Zip)
1. Name and Address of Reporting Person*
5AM CO-INVESTORS II LP
(Last) (First) (Middle)
501 2ND STREET, SUITE 350
(Street)
SAN FRANCISCO CA 94107
(City) (State) (Zip)
1. Name and Address of Reporting Person*
DIEKMAN JOHN D
(Last) (First) (Middle)
501 2ND STREET, SUITE 350
(Street)
SAN FRANCISCO CA 94107
(City) (State) (Zip)
1. Name and Address of Reporting Person*
PARMAR KUSH
(Last) (First) (Middle)
501 2ND STREET, SUITE 350
(Street)
SAN FRANCISCO CA 94107
(City) (State) (Zip)
1. Name and Address of Reporting Person*
ROCKLAGE SCOTT M
(Last) (First) (Middle)
501 2ND STREET, SUITE 350
(Street)
SAN FRANCISCO CA 94107
(City) (State) (Zip)
Explanation of Responses:
1. The securities are directly held by 5AM Ventures VII, L.P. ("Ventures VII"). 5AM Partners VII, LLC ("Partners VII") is the sole general partner of Ventures VII. Dr. Kush Parmar and Andrew J. Schwab are the managing members of Partners VII and may be deemed to have shared voting and investment power over the securities beneficially owned by Ventures VII. Each of Partners VII and Dr. Parmar disclaims beneficial ownership of such securities except to the extent of its or his respective pecuniary interest therein. Mr. Schwab is a director of the Issuer and files separate Section 16 reports.
2. The securities are directly held by 5AM Ventures II, L.P. ("Ventures II"). 5AM Partners II, LLC ("Partners II") is the sole general partner of Ventures II. Dr. John Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are the managing members of Partners II and may be deemed to have shared voting and investment power over the securities beneficially owned by Ventures II. Each of Partners II, Dr. Diekman and Dr. Rocklage disclaims beneficial ownership of such securities except to the extent of its or his respective pecuniary interest therein. Mr. Schwab is a director of the Issuer and files separate Section 16 reports.
3. The securities are directly held by 5AM Co-Investors II, L.P. ("Co-Investors II"). Partners II is the sole general partner of Co-Investors II. Dr. John Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are the managing members of Partners II and may be deemed to have shared voting and investment power over the securities beneficially owned by Co-Investors II. Each of Partners II, Dr. Diekman and Dr. Rocklage disclaims beneficial ownership of such shares except to the extent of its or his respective pecuniary interest therein. Mr. Schwab is a director of the Issuer and files separate Section 16 reports.
5AM Partners VII, LLC, By /s/ Andrew J. Schwab, Managing Member 03/15/2024
5AM Ventures VII, L.P., By: 5AM Partners VII, LLC, its General Partner, By /s/ Andrew J. Schwab, Managing Member 03/15/2024
5AM Partners II, LLC, By /s/ Andrew J. Schwab, Managing Member 03/15/2024
5AM Ventures II L.P., By: 5AM Partners II, LLC, its General Partner, By /s/ Andrew J. Schwab, Managing Member 03/15/2024
5AM Co-Investors II, L.P., By: 5AM Partners II, LLC, its General Partner, By /s/ Andrew J. Schwab, Managing Member 03/15/2024
/s/ John Diekman 03/15/2024
/s/ Kush Parmar 03/15/2024
/s/ Scott M. Rocklage 03/15/2024
** Signature of Reporting Person Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

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