Skye Bioscience, Inc.

11250 El Camino Real, Suite 100

San Diego, CA 92130

May 15, 2024

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549-3720

Attention: Dan Crawford

Re: Skye Bioscience, Inc.

Registration Statement on Form S-3

(File No. 333-279330)

Request for Acceleration

Dear Mr. Crawford:

Pursuant to Rule 461 of the General Rules and Regulations of the Securities and Exchange Commission promulgated under the Securities Act of 1933, as amended, Skye Bioscience, Inc. hereby requests that the effective date of the above-captioned Registration Statement on Form S-3 be accelerated to 4:15 p.m., Eastern Time, on May 17, 2024, or as soon as practicable thereafter. This request is being filed to correct a prior request that the effective date of the above-captioned Registration Statement on Form S-3 be accelerated to 4:15 p.m., Eastern Time, on April 17, 2024, or as soon as practicable thereafter.

Please contact John Hensley of Morrison & Foerster LLP via telephone at (512) 617-0661 or via e-mail at JHensley@mofo.com with any questions you may have. In addition, please notify Mr. Hensley when this request for acceleration has been granted.

Sincerely,
Skye Bioscience, Inc.
/s/ Punit Dhillon
Name: Punit Dhillon
Title: Chief Executive Officer

cc: Kaitlyn Arsenault, Chief Financial Officer

R. John Hensley