EXHIBIT 99.1

JOINT FILING AGREEMENT

The undersigned hereby agree that a single Schedule 13D (or any amendment thereto) relating to the Common Stock of Skye Bioscience, Inc. shall be filed on behalf of each of the undersigned and that this Joint Filing Agreement shall be filed as an exhibit to such Schedule 13D.

Dated: December 19, 2024

5AM Ventures VII, L.P.


By:

5AM Partners VII, LLC

its

General Partner


By:

/s/ Andrew J. Schwab

 

Name: Andrew J. Schwab

Title: Managing Member



5AM Partners VII, LLC


By:

/s/ Andrew J. Schwab

 

Name: Andrew J. Schwab

Title: Managing Member


5AM Ventures II, L.P.


By:

5AM Partners II, LLC

its

General Partner


By:

/s/ Andrew J. Schwab

 

Name: Andrew J. Schwab

Title: Managing Member



5AM Co-Investors II, L.P.


By:

5AM Partners II, LLC

its

General Partner


By:

/s/ Andrew J. Schwab

 

Name: Andrew J. Schwab

Title: Managing Member



5AM Partners II, LLC


By:

/s/ Andrew J. Schwab

 

Name: Andrew J. Schwab

Title: Managing Member



/s/ Andrew J. Schwab

 

Andrew J. Schwab


/s/ Dr. Kush Parmar

Dr. Kush Parmar


/s/ Dr. John D. Diekman

Dr. John D. Diekman


/s/ Dr. Scott M. Rocklage

 

Dr. Scott M. Rocklage