EXHIBIT 5.1

August 12, 2020

Emerald Bioscience, Inc.

5910 Pacific Center Blvd, Suite 320

San Diego, CA 92121

Ladies and Gentlemen:

As legal counsel to Emerald Bioscience, Inc., a Nevada corporation (the “Company”), we have assisted in the preparation of the Company’s Registration Statement on Form S-8 (the “Registration Statement”) to be filed with the Securities and Exchange Commission on or about August 12, 2020 in connection with the registration under the Securities Act of 1933, as amended, of additional shares of the Company’s common stock, par value $0.001 per share (the “Shares”), issuable pursuant to the Company’s 2014 Omnibus Incentive Plan (the “Plan”), as amended by Amendment No. 1 to the 2014 Omnibus Incentive Plan (“Amendment No. 1”) dated as of October 5, 2018, and as further amended by Amendment No. 2 to the 2014 Omnibus Incentive Plan (“Amendment No. 2”) dated as of August 7, 2020. The facts, as we understand them, are set forth in the Registration Statement.

With respect to the opinion set forth below, we have examined originals, certified copies, or copies otherwise identified to our satisfaction as being true copies, only of the following:

A. The Articles of Incorporation of the Company, as filed with the Secretary of State of Nevada;

B. The Bylaws of the Company;

C. Action by Unanimous Written Consent of the Board of Directors of the Company, dated as of August 7, 2020, approving and authorizing, among other things, to file a registration statement on Form S-8 to register 18,486,435 Shares or such other additional amount issued under the Plan;

D. Action by Unanimous Consent in Writing in lieu of a Meeting of the Board of Directors of the Company, dated as of October 5, 2018, approving and adopting Amendment No. 1 and authorizing the issuance of the Shares pursuant to the Plan, as amended by Amendment No. 1;

E. Action by Unanimous Consent in Writing in lieu of a Meeting of the Board of Directors of the Company, dated as of August 7, 2020, approving and adopting Amendment No. 2;

F. The Plan;

G. Amendment No. 1;

H. Amendment No. 2; and

I. The Registration Statement.

Subject to the assumptions that (i) the documents and signatures examined by us are genuine and authentic, and (ii) the persons executing the documents examined by us have the legal capacity to execute such documents, and based solely upon our review of items A through I above, and subject to the further limitations and qualifications set forth below, it is our opinion that the Shares, when issued and sold in accordance with the Plan, as amended, will be validly issued, fully paid, and nonassessable.

We express no opinion as to the applicability or effect of any laws, orders, or judgments of any state or other jurisdiction other than federal securities laws and the substantive laws of the state of Nevada, including judicial interpretations of such laws. Further, our opinion is based solely upon existing laws, rules, and regulations, and we undertake no obligation to advise you of any changes that may be brought to our attention after the date hereof.

We hereby expressly consent to any reference to our firm in the Registration Statement, inclusion of this Opinion as an exhibit to the Registration Statement, and to the filing of this Opinion with any other appropriate governmental agency.