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We consent to the incorporation by reference in the Registration Statement of Skye Bioscience, Inc. and Subsidiaries on Form S-3 (Registration No. 333-258243) and Form S-8 (Nos. 333-245177, 333-227860, 333-276211 and 333-223439) of our report dated March 21, 2024, with respect to our audits of the consolidated financial statements of Skye Bioscience, Inc. and Subsidiaries as of December 31, 2023 and 2022 and for the years ended December 31, 2023 and 2022, which report is included in this Annual Report on Form 10-K of Skye Bioscience, Inc. and Subsidiaries for the year ended December 31, 2023.