Subsidiaries of the Registrant

Name of Entity			Formation Date			Jurisdiction of Incorporation			Holder of Stock
Nemus			July 17, 2012			California, USA			Skye Bioscience, Inc.
Skye Bioscience Pty Ltd.			August 9, 2019			Australia			Skye Bioscience, Inc.
Emerald Health Therapeutics, Inc.			July 31, 2007			British Columbia, Canada			Skye Bioscience, Inc.
Avalite Sciences, Inc.			March 3, 2005			British Columbia, Canada			Emerald Health Therapeutics, Inc.
Bird Rock Bio Sub, Inc.			November 16, 2006			Delaware, USA			Skye Bioscience, Inc.
Ruiyi Acquisition Corporation			July 21, 2011			Delaware, USA			Bird Rock Bio Sub, Inc.