Subsidiaries of the Registrant


Name of EntityFormation DateJurisdiction of IncorporationHolder of Stock
NemusJuly 17, 2012California, USASkye Bioscience, Inc.
Skye Bioscience Pty Ltd.August 9, 2019AustraliaSkye Bioscience, Inc.
Emerald Health Therapeutics, Inc.July 31, 2007British Columbia, CanadaSkye Bioscience, Inc.
Avalite Sciences, Inc.March 3, 2005British Columbia, CanadaEmerald Health Therapeutics, Inc.
Bird Rock Bio Sub, Inc.November 16, 2006Delaware, USASkye Bioscience, Inc.
Ruiyi Acquisition CorporationJuly 21, 2011Delaware, USABird Rock Bio Sub, Inc.