Annual report pursuant to Section 13 and 15(d)

Warrants and Derivative Liabilities - Schedule of Warrants Vested and Outstanding (Details)

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Warrants and Derivative Liabilities - Schedule of Warrants Vested and Outstanding (Details) - $ / shares
 12 Months Ended
Dec. 31, 2021
Jul. 26, 2021
Class of Warrant or Right [Line Items]    
Number of Warrants Vested and Outstanding (in shares) 154,458,892  
Pre 2015 Common Stock Warrants    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 1.00  
Term (Years) 10 years  
Number of Warrants Vested and Outstanding (in shares) 1,110,000  
2015 Common Stock Warrants    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 5.00  
Term (Years) 10 years  
Number of Warrants Vested and Outstanding (in shares) 100,000  
2016 Common Stock Warrants to Service Providers    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 1.15  
Term (Years) 10 years  
Number of Warrants Vested and Outstanding (in shares) 40,000  
2017 Series D Common Stock Warrants to Placement Agent    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 0.25  
Term (Years) 5 years  
Number of Warrants Vested and Outstanding (in shares) 480,000  
2017 Common Stock Warrants to Service Provider    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 0.41  
Term (Years) 5 years  
Number of Warrants Vested and Outstanding (in shares) 125,000  
2018 Emerald Financing Warrants    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 0.10  
Term (Years) 5 years  
Number of Warrants Vested and Outstanding (in shares) 3,400,000  
Emerald Multi-Draw Credit Agreement Warrants    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 0.50  
Term (Years) 5 years  
Number of Warrants Vested and Outstanding (in shares) 7,500,000  
2019 Common Stock Warrants    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 0.35  
Term (Years) 5 years  
Number of Warrants Vested and Outstanding (in shares) 8,000,000  
2020 Common Stock Warrants to Placement Agent    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 0.08  
Term (Years) 4 years 11 months 26 days  
Number of Warrants Vested and Outstanding (in shares) 8,166,667  
2021 Inducement Warrants    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 0.15 $ 0.06
Term (Years) 5 years  
Number of Warrants Vested and Outstanding (in shares) 21,166,667  
2021 Inducement Warrants to Placement Agent    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 0.19  
Term (Years) 5 years  
Number of Warrants Vested and Outstanding (in shares) 1,481,667  
2021 Common Stock Warrants    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 0.09  
Term (Years) 5 years  
Number of Warrants Vested and Outstanding (in shares) 77,777,779  
2021 Pre-Funded Warrants    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 0.0001  
Number of Warrants Vested and Outstanding (in shares) 19,666,667  
2021 Common Stock Warrants to Placement Agent    
Class of Warrant or Right [Line Items]    
Exercise price (in dollars per share) $ 0.11  
Term (Years) 5 years  
Number of Warrants Vested and Outstanding (in shares) 5,444,445