Annual report pursuant to Section 13 and 15(d)


Cover - USD ($)
12 Months Ended
Dec. 31, 2021
Mar. 24, 2022
Jun. 30, 2021
Cover [Abstract]      
Document Type 10-K    
Document Annual Report true    
Document Period End Date Dec. 31, 2021    
Current Fiscal Year End Date --12-31    
Document Transition Report false    
Entity File Number 000-55136    
Entity Registrant Name Skye Bioscience, Inc.    
Entity Incorporation, State or Country Code NV    
Entity Tax Identification Number 45-0692882    
Entity Address, Address Line One 11250 El Camino Real    
Entity Address, Address Line Two Suite 100    
Entity Address, City or Town San Diego    
Entity Address, State or Province CA    
Entity Address, Postal Zip Code 92130    
City Area Code 858    
Local Phone Number 410-0266    
Title of 12(g) Security Common Stock, Par Value $0.001    
Entity Well-known Seasoned Issuer No    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Non-accelerated Filer    
Entity Small Business true    
Entity Emerging Growth Company false    
Entity Shell Company false    
Entity Public Float     $ 45,310,946
Entity Common Stock, Shares Outstanding   495,925,112  
Entity Central Index Key 0001516551    
Amendment Flag false    
Document Fiscal Year Focus 2021    
Document Fiscal Period Focus FY