Quarterly report pursuant to Section 13 or 15(d)


Cover - shares
6 Months Ended
Jun. 30, 2021
Aug. 04, 2021
Cover [Abstract]    
Document Type 10-Q  
Document Quarterly Report true  
Document Period End Date Jun. 30, 2021  
Document Transition Report false  
Entity File Number 000-55136  
Entity Registrant Name Skye Bioscience, Inc.  
Entity Incorporation, State or Country Code NV  
Entity Tax Identification Number 45-0692882  
Entity Address, Address Line One 5910 Pacific Center Blvd  
Entity Address, Address Line Two Suite 320  
Entity Address, City or Town San Diego  
Entity Address, State or Province CA  
Entity Address, Postal Zip Code 92121  
City Area Code 949  
Local Phone Number 480-9051  
Title of 12(g) Security Common Stock, par value $0.001  
Trading Symbol SKYE  
Entity Current Reporting Status Yes  
Entity Interactive Data Current Yes  
Entity Filer Category Non-accelerated Filer  
Entity Small Business true  
Entity Emerging Growth Company false  
Entity Shell Company false  
Entity Common Stock, Shares Outstanding   417,247,333
Entity Central Index Key 0001516551  
Current Fiscal Year End Date --12-31  
Amendment Flag false  
Document Fiscal Year Focus 2021  
Document Fiscal Period Focus Q2